Table 3.
HMGA2 Genotype Associations with Anthropometric and Bone Mineral Density Measures in Caucasian Men.
| Trait | Genotype Mean (SE) |
p-valueb | ||
|---|---|---|---|---|
| C/C (n=423) | C/T (n=768) | T/T (n=357) | ||
| Height (cm) | 173.38(0.34) | 172.89(0.25) | 172.69(0.38) | 0.1640a |
| Weight (kg) | 84.24(0.67) | 83.39(0.49) | 83.19(0.74) | 0.2719a |
| Radius BMD (mg/cm3) | ||||
| Trabecular | 200(3) | 197(2) | 193(3) | 0.0996a |
| Cortical | 1159(2) | 1160(1) | 1158(2) | 0.6211r |
| Tibia BMD (mg/cm3) | ||||
| Trabecular | 235(2) | 232(2) | 223(3) | 0.0007a |
| Cortical | 1136(2) | 1136(1) | 1133(2) | 0.1779r |
| Proximal Femur BMD(g/cm2) | ||||
| Total Hip | 0.96(0.01) | 0.97(0.01) | 0.96(0.01) | 0.3718r |
| Femoral Neck | 0.79(0.01) | 0.79(0.01) | 0.79(0.01) | 0.7643r |
b
p-value of the best fit model are shown, age and site adjusted;
a
additive model;
r
recessive model; total n for DXA measures is 1398 and for pQCT measures is 1068. The P values highlighted in bold face achieve Bonferroni adjusted statistical significance accounting for the six BMD traits (P<0.008).