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. 1988 Apr;85(7):2362–2366. doi: 10.1073/pnas.85.7.2362

Expression of varicella-zoster virus and herpes simplex virus in normal human trigeminal ganglia.

A Vafai 1, R S Murray 1, M Wellish 1, M Devlin 1, D H Gilden 1
PMCID: PMC279992  PMID: 2832852

Abstract

Lysates of radiolabeled explants from four human trigeminal ganglia were immunoprecipitated with antibodies to varicella-zoster virus (VZV) and to herpes simplex virus. Both herpes simplex virus- and VZV-specific proteins were detected in lysates of all four ganglia. Absence of reactivity in ganglion explants with monoclonal antibodies suggested that herpes simplex virus and VZV were not reactivated during the culture period. In situ hybridization studies demonstrated the presence of RNA transcripts from the VZV immediate early gene 63. This approach to the detection of herpes simplex virus and VZV expression in human ganglia should facilitate analysis of viral RNA and proteins in human sensory ganglia.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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