Skip to main content
. Author manuscript; available in PMC: 2010 Dec 9.
Published in final edited form as: Structure. 2009 Dec 9;17(12):1551–1557. doi: 10.1016/j.str.2009.07.019

Figure 3. Cyclic Nucleotide Recognition.

Figure 3

A) Binding pocket interactions between cGMP and PDE2A GAF B.

B) Binding pocket interactions between cGMP and PDE5A GAF A.

C) Binding pocket interactions between cGMP and PDE6C GAF A.

D) Binding pocket interactions between cAMP and PDE10A GAF B.

E) Interaction between α2/3 and Asn116 in PDE6C GAF A. Ser121 and Asn126 make hydrogen bond contacts to Asn116, which in turn makes nucleotide-specific contact with cGMP.

F) PDE10A GAF B does not contain α2/3. The motion range of Asp305 appears less restricted and it is rotated out to accommodate Arg286, which in turn makes nucleotide-specific contact with cAMP.