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. 1988 May;85(9):3245–3249. doi: 10.1073/pnas.85.9.3245

Bradykinin as a pain mediator: receptors are localized to sensory neurons, and antagonists have analgesic actions.

L R Steranka 1, D C Manning 1, C J DeHaas 1, J W Ferkany 1, S A Borosky 1, J R Connor 1, R J Vavrek 1, J M Stewart 1, S H Snyder 1
PMCID: PMC280181  PMID: 2896357

Abstract

Autoradiographic studies localize [3H]bradykinin receptor binding sites to the substantia gelatinosa, dorsal root, and a subset of small cells in both the dorsal root and trigeminal ganglia of the guinea pig. [3H]Bradykinin labeling is also observed over myocardial/coronary visceral afferent fibers. The localization of [3H]bradykinin receptors to nociceptive pathways supports a role for bradykinin in pain mediation. Several bradykinin antagonists block bradykinin-induced acute vascular pain in the rat. The bradykinin antagonists also relieve bradykinin- and urate-induced hyperalgesia in the rat paw. These results indicate that bradykinin is a physiologic mediator of pain and that bradykinin antagonists have analgesic activity in both acute and chronic pain models.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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