Table.

Responses to Chronic MC3/4-R Blockade on Body wt, Plasma Hormones, and Renal Function in SHR and WKY Rats

Experimental Groups	Body Weight, g	Glucose, mmol/L	Insulin, ng/mL	Leptin, ng/mL	PRA, ng AI/mL/h	GFR, mL/min
SHR (n=5)
Control	329±10†	6.2±0.3	5.3±1.3	6.7±3.4	5.4±3.4	3.8±0.3
SHU-9119	397±16*†	6.4±0.4	17.4±1.3*	12.8±3.7*	9.6±1.2*†	4.7±0.3*†
Recovery	386±10*†	6.1±0.3	4.9±1.0	2.2±0.1*†	9.1±0.8*†	4.5±0.2*
WKY (n=5)
Control	462±14	6.3±0.2	3.8±0.8	2.4±0.7	5.7±0.8	3.8±0.4
SHU-9119	593±22*	6.4±0.6	15.2±1.3*	18.8±2.3*	6.9±0.6	6.4±0.6*
Recovery	588±28*	6.4±0.4	7.3±2.4	12.3±3.1*†	5.9±0.4	4.8±0.3*

PRA indicates plasma renin activity; GFR, glomerular filtration rate. Values were determined on day 5 of control period, day 11 of SHU-9119 treatment, and day 5 of recovery period.

^*P<0.05 vs control;

^†P<0.05 vs WKY.