Skip to main content
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1988 Jun;85(11):4030–4031. doi: 10.1073/pnas.85.11.4030

Active transport of urea by mammalian kidney.

K H Beyer Jr 1, R T Gelarden 1
PMCID: PMC280354  PMID: 3131771

Abstract

With the aid of three basic organic compounds, 2-pyrazinoylguanidine, 3-amino-2-pyrazinoylguanidine, and 3,5-diamino-6-fluoro-2-pyrazinoylguanidine, urea was shown to be secreted by the renal tubules of the dog both from the lumen and into the lumen independent of urine flow.

Full text

PDF
4030

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BEYER K. H., RUSSO H. F., TILLSON E. K., MILLER A. K., VERWEY W. F., GASS S. R. 'Benemid,' p-(di-n-propylsulfamyl)-benzoic acid; its renal affinity and its elimination. Am J Physiol. 1951 Sep;166(3):625–640. doi: 10.1152/ajplegacy.1951.166.3.625. [DOI] [PubMed] [Google Scholar]
  2. BEYER K. H. The mechanism of action of chlorothiazide. Ann N Y Acad Sci. 1958 Feb 3;71(4):363–379. doi: 10.1111/j.1749-6632.1958.tb46763.x. [DOI] [PubMed] [Google Scholar]
  3. Danielson R. A., Schmidt-Nielsen B. Recirculation of urea analogs from renal collecting ducts of high- and low-protein-fed rats. Am J Physiol. 1972 Jul;223(1):130–137. doi: 10.1152/ajplegacy.1972.223.1.130. [DOI] [PubMed] [Google Scholar]
  4. FORSTER R. P. Active cellular transport of urea by frog renal tubules. Am J Physiol. 1954 Nov;179(2):372–377. doi: 10.1152/ajplegacy.1954.179.2.372. [DOI] [PubMed] [Google Scholar]
  5. FORSTER R. P., BERGLUND F. Contrasting inhibitory effects of probenecid on the renal tubular excretion of p-aminohippurate and on the active reabsorption of urea in the dogfish, Squalus acanthias. J Cell Physiol. 1957 Apr;49(2):281–285. doi: 10.1002/jcp.1030490209. [DOI] [PubMed] [Google Scholar]
  6. Goldberg M., Wojtczak A. M., Ramirez M. A. Uphill transport of urea in the dog kidney: effects of certain inhibitors. J Clin Invest. 1967 Mar;46(3):388–399. doi: 10.1172/JCI105540. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. LASSITER W. E., MYLLE M., GOTTSCHALK C. W. NET TRANSTUBULAR MOVEMENT OF WATER AND UREA IN SALINE DIURESIS. Am J Physiol. 1964 Apr;206:669–673. doi: 10.1152/ajplegacy.1964.206.4.669. [DOI] [PubMed] [Google Scholar]
  8. Ullrich K. J., Rumrich G., Schmidt-Nielsen B. Urea transport in the collecting duct of rats on normal and low protein diet. Pflugers Arch Gesamte Physiol Menschen Tiere. 1967;295(2):147–156. doi: 10.1007/BF00362746. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES