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. 1988 Jun;85(12):4451–4454. doi: 10.1073/pnas.85.12.4451

HLA class I molecules are associated with CD1a heavy chains on normal human thymus cells.

M Amiot 1, H Dastot 1, L Degos 1, J Dausset 1, A Bernard 1, L Boumsell 1
PMCID: PMC280447  PMID: 2454469

Abstract

The molecules encoded by the major histocompatibility complex play a pivotal role in regulatory interactions between cells of the immune system, which can result in the activation and function of T cells. The function of the CD1 molecules, which are homologous to the major histocompatibility complex-encoded molecules but are encoded on human chromosome 1, is not known. HLA class I molecules and CD1a heavy chains share the ability to associate with several different cell-surface molecules. We show here, by several technical approaches, that HLA class I molecules are associated with CD1a heavy chains on the surface of normal thymus cells. The functional significance of this association during T-cell differentiation is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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