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. 1988 Jun;85(12):4460–4462. doi: 10.1073/pnas.85.12.4460

Protective immunity and eosinophilia in IgE-deficient SJA/9 mice infected with Nippostrongylus brasiliensis and Trichinella spiralis.

N Watanabe 1, K Katakura 1, A Kobayashi 1, K Okumura 1, Z Ovary 1
PMCID: PMC280449  PMID: 3380800

Abstract

To elucidate the roles of IgE antibody in host responses to helminth infection, selective IgE-deficient SJA/9 mice were infected with the nematode parasites Nippostrongylus brasiliensis, which elicits remarkable potentiated IgE production, and Trichinella spiralis, which induces strong anti-Trichinella IgE antibody production in normal mice. The kinetics of blood eosinophilia, worm burden after primary infection, and resistance to secondary infection in SJA/9 mice were the same in both infections as those in congenic SJL/J mice used as an IgE-producing control. These results indicate that the host responses examined here operate under IgE-independent mechanisms.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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