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A) Central tendency, a measure of anxiety-like behavior, was decreased in all mice exposed to CA/CPR relative to SHAM. CA/CPR+STRESS further decreased central tendency relative to CA/CPR. Restraint had no effect among SHAM mice. B) In Experiment 2, CA/CPR reduced central tendency relative to SHAM, and this effect was blocked by administration of minocycline. Data are presented as mean ± SEM; bars with different letters are statistically different (p < 0.05).
