Table 3.

Selected Genes Differing Between Future RRs and SRs with a Fold Change Greater Than or Equal to 1.5 (P ≤ 0.01) in the Pretreatment Group

Gene Category	Gene Name	Gene Symbol	Fold Change (RR/SR)	P
ISG	2′,5′-Oligoadenylate synthetase 2*†	OAS2	−2.4	0.02
	2′,5′-Oligoadenylate synthetase 3*†	OAS3	−2.4	0.01
	IFN-induced transmembrane protein 1	IFITM1	−2.3	0.001
	IFN-induced transmembrane protein 3	IFITM3	−1.5	0.004
	IFN-alpha–inducible protein (ISG-15)*†	G1P2/ISG15	−3.2	0.028
	IFN-alpha–inducible protein (IFI-6–16)†	G1P3/IFI6	−3.0	0.0016
	IFN-alpha–inducible protein 27	IFI27	−3.7	0.004
	IFN-induced protein 35	IFI35	−2.3	0.0048
	IFN-induced protein 44	IFI44	−2.7	0.001
	IFN-induced protein with TTPR 1†	IFIT1	−2.8	0.01
	IFN-induced protein with TTPR 3	IFIT3	−2.6	0.0075
	Myxovirus resistance 1†	MX1	−3.9	0.0004
	Phospholipid scramblase 1	PLSCR1	−2.0	0.003
	Ubiquitin-specific peptidase 18*†	USP18	−1.7	0.042
	Viperin†	RSAD2	−3.3	0.0008
IFN-Related	RIG-I DEAD box polypeptide 58	DDX58	−2.0	0.01
	Signal transducer activator of transcription 1	STAT1	−2.0	0.0048
Other	Activating transcription factor 7 interacting protein 2†	ATF7IP2	1.7	0.0083
	Chemokine ligand 9 (MIG)	CXCL9	2.9	0.0062
	Leucine aminopeptidase 3*†	LAP3	−1.5	0.030
	Ribosomal protein S28†	RPS28	1.98	0.0077
	Syntaxin binding protein 5-like†	STXBP5L	6.4	0.0003

^*P between 0.05 and 0.01.

^†Gene identified by Chen et al.⁶ as differing between future sustained responders and future nonresponders. Abbreviations: IFN, interferon; ISG, interferon-stimulated gene.