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. 1993 May;61(5):2196–2199. doi: 10.1128/iai.61.5.2196-2199.1993

Cell-mediated immunity to Chlamydia pneumoniae measured as lymphocyte blast transformation in vitro.

H M Surcel 1, H Syrjälä 1, M Leinonen 1, P Saikku 1, E Herva 1
PMCID: PMC280821  PMID: 8478110

Abstract

The purpose of the present study was to analyze Chlamydia pneumoniae-induced, antigen-specific, cell-mediated immunity. Peripheral blood mononuclear cells of four persons infected with C. pneumoniae Kajaani 6 and 17 healthy volunteers were stimulated with antigen composed of whole elementary bodies of C. pneumoniae Kajaani 6 (CP-Ag). Definitive antigen-specific lymphoproliferation (LP) responses were developed after recent infection. The LP responses of healthy people to CP-Ag varied considerably. There was no clear correlation between LP responses to CP-Ag and those to an antigen prepared from Chlamydia trachomatis serotype L2 (r > or = 0.50, P < 0.1). A larger study is required to demonstrate whether the LP responses to CP-Ag can be used for the diagnosis of C. pneumoniae infection.

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Selected References

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