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. 1993 May;61(5):2229–2232. doi: 10.1128/iai.61.5.2229-2232.1993

Antigenic and functional differences in adhesion of Plasmodium falciparum-infected erythrocytes to human and bovine CD36.

C F Ockenhouse 1, N N Tandon 1, G A Jamieson 1, D E Greenwalt 1
PMCID: PMC280829  PMID: 7683005

Abstract

Cytoadherence by Plasmodium falciparum-infected erythrocytes (PRBC) to microvascular endothelium is, in part, mediated by the specific interaction between a parasite-derived erythrocyte surface ligand and a specific binding site on human CD36. We describe the selection for increased adhesion of PRBC to bovine CD36 and demonstrate that the molecular interaction between PRBC and bovine CD36 is independent of and distinct from the OKM5/8 monoclonal antibody epitopes which block PRBC-human CD36 binding.

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Selected References

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  1. Alessio M., Ghigo D., Garbarino G., Geuna M., Malavasi F. Analysis of the human CD36 leucocyte differentiation antigen by means of the monoclonal antibody NL07. Cell Immunol. 1991 Oct 15;137(2):487–500. doi: 10.1016/0008-8749(91)90096-t. [DOI] [PubMed] [Google Scholar]
  2. Asch A. S., Barnwell J., Silverstein R. L., Nachman R. L. Isolation of the thrombospondin membrane receptor. J Clin Invest. 1987 Apr;79(4):1054–1061. doi: 10.1172/JCI112918. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Barnwell J. W., Asch A. S., Nachman R. L., Yamaya M., Aikawa M., Ingravallo P. A human 88-kD membrane glycoprotein (CD36) functions in vitro as a receptor for a cytoadherence ligand on Plasmodium falciparum-infected erythrocytes. J Clin Invest. 1989 Sep;84(3):765–772. doi: 10.1172/JCI114234. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Barnwell J. W., Ockenhouse C. F., Knowles D. M., 2nd Monoclonal antibody OKM5 inhibits the in vitro binding of Plasmodium falciparum-infected erythrocytes to monocytes, endothelial, and C32 melanoma cells. J Immunol. 1985 Nov;135(5):3494–3497. [PubMed] [Google Scholar]
  5. Biggs B. A., Anders R. F., Dillon H. E., Davern K. M., Martin M., Petersen C., Brown G. V. Adherence of infected erythrocytes to venular endothelium selects for antigenic variants of Plasmodium falciparum. J Immunol. 1992 Sep 15;149(6):2047–2054. [PubMed] [Google Scholar]
  6. Catimel B., McGregor J. L., Hasler T., Greenwalt D. E., Howard R. J., Leung L. L. Epithelial membrane glycoprotein PAS-IV is related to platelet glycoprotein IIIb binding to thrombospondin but not to malaria-infected erythrocytes. Blood. 1991 Jun 15;77(12):2649–2654. [PubMed] [Google Scholar]
  7. Corcoran L. M., Forsyth K. P., Bianco A. E., Brown G. V., Kemp D. J. Chromosome size polymorphisms in Plasmodium falciparum can involve deletions and are frequent in natural parasite populations. Cell. 1986 Jan 17;44(1):87–95. doi: 10.1016/0092-8674(86)90487-3. [DOI] [PubMed] [Google Scholar]
  8. Greenwalt D. E., Johnson V. G., Mather I. H. Specific antibodies to PAS IV, a glycoprotein of bovine milk-fat-globule membrane, bind to a similar protein in cardiac endothelial cells and epithelial cells of lung bronchioles. Biochem J. 1985 May 15;228(1):233–240. doi: 10.1042/bj2280233. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Greenwalt D. E., Watt K. W., Hasler T., Howard R. J., Patel S. Structural, functional, and antigenic differences between bovine heart endothelial CD36 and human platelet CD36. J Biol Chem. 1990 Sep 25;265(27):16296–16299. [PubMed] [Google Scholar]
  10. Greenwalt D. E., Watt K. W., So O. Y., Jiwani N. PAS IV, an integral membrane protein of mammary epithelial cells, is related to platelet and endothelial cell CD36 (GP IV). Biochemistry. 1990 Jul 31;29(30):7054–7059. doi: 10.1021/bi00482a015. [DOI] [PubMed] [Google Scholar]
  11. Leech J. H., Barnwell J. W., Miller L. H., Howard R. J. Identification of a strain-specific malarial antigen exposed on the surface of Plasmodium falciparum-infected erythrocytes. J Exp Med. 1984 Jun 1;159(6):1567–1575. doi: 10.1084/jem.159.6.1567. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Ockenhouse C. F., Chulay J. D. Plasmodium falciparum sequestration: OKM5 antigen (CD36) mediates cytoadherence of parasitized erythrocytes to a myelomonocytic cell line. J Infect Dis. 1988 Mar;157(3):584–588. doi: 10.1093/infdis/157.3.584. [DOI] [PubMed] [Google Scholar]
  13. Ockenhouse C. F., Ho M., Tandon N. N., Van Seventer G. A., Shaw S., White N. J., Jamieson G. A., Chulay J. D., Webster H. K. Molecular basis of sequestration in severe and uncomplicated Plasmodium falciparum malaria: differential adhesion of infected erythrocytes to CD36 and ICAM-1. J Infect Dis. 1991 Jul;164(1):163–169. doi: 10.1093/infdis/164.1.163. [DOI] [PubMed] [Google Scholar]
  14. Ockenhouse C. F., Klotz F. W., Tandon N. N., Jamieson G. A. Sequestrin, a CD36 recognition protein on Plasmodium falciparum malaria-infected erythrocytes identified by anti-idiotype antibodies. Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3175–3179. doi: 10.1073/pnas.88.8.3175. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Ockenhouse C. F., Tandon N. N., Magowan C., Jamieson G. A., Chulay J. D. Identification of a platelet membrane glycoprotein as a falciparum malaria sequestration receptor. Science. 1989 Mar 17;243(4897):1469–1471. doi: 10.1126/science.2467377. [DOI] [PubMed] [Google Scholar]
  16. Oquendo P., Hundt E., Lawler J., Seed B. CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Cell. 1989 Jul 14;58(1):95–101. doi: 10.1016/0092-8674(89)90406-6. [DOI] [PubMed] [Google Scholar]
  17. Roberts D. J., Craig A. G., Berendt A. R., Pinches R., Nash G., Marsh K., Newbold C. I. Rapid switching to multiple antigenic and adhesive phenotypes in malaria. Nature. 1992 Jun 25;357(6380):689–692. doi: 10.1038/357689a0. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Sieg K., Kun J., Pohl I., Scherf A., Müller-Hill B. A versatile phage lambda expression vector system for cloning in Escherichia coli. Gene. 1989 Feb 20;75(2):261–270. doi: 10.1016/0378-1119(89)90272-2. [DOI] [PubMed] [Google Scholar]
  19. Swerlick R. A., Lee K. H., Wick T. M., Lawley T. J. Human dermal microvascular endothelial but not human umbilical vein endothelial cells express CD36 in vivo and in vitro. J Immunol. 1992 Jan 1;148(1):78–83. [PubMed] [Google Scholar]
  20. Tandon N. N., Kralisz U., Jamieson G. A. Identification of glycoprotein IV (CD36) as a primary receptor for platelet-collagen adhesion. J Biol Chem. 1989 May 5;264(13):7576–7583. [PubMed] [Google Scholar]
  21. Tandon N. N., Lipsky R. H., Burgess W. H., Jamieson G. A. Isolation and characterization of platelet glycoprotein IV (CD36). J Biol Chem. 1989 May 5;264(13):7570–7575. [PubMed] [Google Scholar]
  22. Tandon N. N., Ockenhouse C. F., Greco N. J., Jamieson G. A. Adhesive functions of platelets lacking glycoprotein IV (CD36). Blood. 1991 Dec 1;78(11):2809–2813. [PubMed] [Google Scholar]
  23. Vega M. A., Seguí-Real B., García J. A., Calés C., Rodríguez F., Vanderkerckhove J., Sandoval I. V. Cloning, sequencing, and expression of a cDNA encoding rat LIMP II, a novel 74-kDa lysosomal membrane protein related to the surface adhesion protein CD36. J Biol Chem. 1991 Sep 5;266(25):16818–16824. [PubMed] [Google Scholar]
  24. Yamamoto N., Ikeda H., Tandon N. N., Herman J., Tomiyama Y., Mitani T., Sekiguchi S., Lipsky R., Kralisz U., Jamieson G. A. A platelet membrane glycoprotein (GP) deficiency in healthy blood donors: Naka- platelets lack detectable GPIV (CD36). Blood. 1990 Nov 1;76(9):1698–1703. [PubMed] [Google Scholar]

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