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. 1993 May;61(5):2242–2244. doi: 10.1128/iai.61.5.2242-2244.1993

Cutaneous leishmaniasis in mast cell-deficient W/Wv mice.

K Katakura 1, S Saito 1, A Hamada 1, H Matsuda 1, N Watanabe 1
PMCID: PMC280832  PMID: 8478118

Abstract

Genetically mast cell-deficient W/Wv mice infected with Leishmania amazonensis showed progressive development of ulcerative skin lesions. However, no significant differences between the W/Wv mice and the normal littermates with respect to size of the lesions, anti-Leishmania immunoglobulin E antibody, and the number of eosinophils accumulated in the lesions were observed.

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Selected References

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  1. Alexander J., Russell D. G. The interaction of Leishmania species with macrophages. Adv Parasitol. 1992;31:175–254. doi: 10.1016/s0065-308x(08)60022-6. [DOI] [PubMed] [Google Scholar]
  2. Barral-Netto M., Barral A., Brownell C. E., Skeiky Y. A., Ellingsworth L. R., Twardzik D. R., Reed S. G. Transforming growth factor-beta in leishmanial infection: a parasite escape mechanism. Science. 1992 Jul 24;257(5069):545–548. doi: 10.1126/science.1636092. [DOI] [PubMed] [Google Scholar]
  3. Brown M. A., Pierce J. H., Watson C. J., Falco J., Ihle J. N., Paul W. E. B cell stimulatory factor-1/interleukin-4 mRNA is expressed by normal and transformed mast cells. Cell. 1987 Aug 28;50(5):809–818. doi: 10.1016/0092-8674(87)90339-4. [DOI] [PubMed] [Google Scholar]
  4. Chatelain R., Varkila K., Coffman R. L. IL-4 induces a Th2 response in Leishmania major-infected mice. J Immunol. 1992 Feb 15;148(4):1182–1187. [PubMed] [Google Scholar]
  5. Grimaldi G., Jr, Soares M. J., Moriearty P. L. Tissue eosinophilia and Leishmania mexicana mexicana eosinophil interactions in murine cutaneous leishmaniasis. Parasite Immunol. 1984 Sep;6(5):397–408. doi: 10.1111/j.1365-3024.1984.tb00811.x. [DOI] [PubMed] [Google Scholar]
  6. Heinzel F. P., Sadick M. D., Holaday B. J., Coffman R. L., Locksley R. M. Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J Exp Med. 1989 Jan 1;169(1):59–72. doi: 10.1084/jem.169.1.59. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hirano T., Miyajima H., Kitagawa H., Watanabe N., Azuma M., Taniguchi O., Hashimoto H., Hirose S., Yagita H., Furusawa S. Studies on murine IgE with monoclonal antibodies. I. Characterization of rat monoclonal anti-IgE antibodies and the use of these antibodies for determinations of serum IgE levels and for anaphylactic reactions. Int Arch Allergy Appl Immunol. 1988;85(1):47–54. [PubMed] [Google Scholar]
  8. Kitamura Y. Heterogeneity of mast cells and phenotypic change between subpopulations. Annu Rev Immunol. 1989;7:59–76. doi: 10.1146/annurev.iy.07.040189.000423. [DOI] [PubMed] [Google Scholar]
  9. Lee T. D., Swieter M., Befus A. D. Mast cell responses to helminth infection. Parasitol Today. 1986 Jul;2(7):186–191. doi: 10.1016/0169-4758(86)90190-0. [DOI] [PubMed] [Google Scholar]
  10. Liew F. Y. Functional heterogeneity of CD4+ T cells in leishmaniasis. Immunol Today. 1989 Feb;10(2):40–45. doi: 10.1016/0167-5699(89)90302-2. [DOI] [PubMed] [Google Scholar]
  11. Lynch N. R., Malavé C., Turner K. J., Infante B. IgE antibody against surface antigens of Leishmania promastigotes in American cutaneous leishmaniasis. Parasite Immunol. 1986 Mar;8(2):109–116. doi: 10.1111/j.1365-3024.1986.tb00837.x. [DOI] [PubMed] [Google Scholar]
  12. Matsuda H., Fukui K., Kiso Y., Kitamura Y. Inability of genetically mast cell-deficient W/Wv mice to acquire resistance against larval Haemaphysalis longicornis ticks. J Parasitol. 1985 Aug;71(4):443–448. [PubMed] [Google Scholar]
  13. Matsuda H., Watanabe N., Kiso Y., Hirota S., Ushio H., Kannan Y., Azuma M., Koyama H., Kitamura Y. Necessity of IgE antibodies and mast cells for manifestation of resistance against larval Haemaphysalis longicornis ticks in mice. J Immunol. 1990 Jan 1;144(1):259–262. [PubMed] [Google Scholar]
  14. McElrath M. J., Kaplan G., Nusrat A., Cohn Z. A. Cutaneous leishmaniasis. The defect in T cell influx in BALB/c mice. J Exp Med. 1987 Feb 1;165(2):546–559. doi: 10.1084/jem.165.2.546. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Mosmann T. R., Coffman R. L. Heterogeneity of cytokine secretion patterns and functions of helper T cells. Adv Immunol. 1989;46:111–147. doi: 10.1016/s0065-2776(08)60652-5. [DOI] [PubMed] [Google Scholar]
  16. Plaut M., Pierce J. H., Watson C. J., Hanley-Hyde J., Nordan R. P., Paul W. E. Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophores. Nature. 1989 May 4;339(6219):64–67. doi: 10.1038/339064a0. [DOI] [PubMed] [Google Scholar]
  17. Scott P., Natovitz P., Coffman R. L., Pearce E., Sher A. Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J Exp Med. 1988 Nov 1;168(5):1675–1684. doi: 10.1084/jem.168.5.1675. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Scott P., Pearce E., Cheever A. W., Coffman R. L., Sher A. Role of cytokines and CD4+ T-cell subsets in the regulation of parasite immunity and disease. Immunol Rev. 1989 Dec;112:161–182. doi: 10.1111/j.1600-065x.1989.tb00557.x. [DOI] [PubMed] [Google Scholar]
  19. Watanabe N., Ovary Z. Antigen and antibody detection by in vivo methods; a reevaluation of passive cutaneous anaphylactic reactions. J Immunol Methods. 1977;14(3-4):381–390. doi: 10.1016/0022-1759(77)90149-1. [DOI] [PubMed] [Google Scholar]

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