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. 1993 May;61(5):2245–2248. doi: 10.1128/iai.61.5.2245-2248.1993

Characterization of an aromatic amino acid-dependent Listeria monocytogenes mutant: attenuation, persistence, and ability to induce protective immunity in mice.

J E Alexander 1, P W Andrew 1, D Jones 1, I S Roberts 1
PMCID: PMC280833  PMID: 8478119

Abstract

A transposon insertion mutant of Listeria monocytogenes was shown to be deficient in prephenate dehydratase, an enzyme acting late in the pathway for biosynthesis of phenylalanine. This mutant had reduced virulence in mice. The mutant and parent strains persisted to the same extent in the tissues of infected mice and elicited similar degrees of splenomegaly. Mice vaccinated with the mutant were protected significantly from subsequent challenge with virulent L. monocytogenes.

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Selected References

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