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. 1993 May;61(5):2260–2265. doi: 10.1128/iai.61.5.2260-2265.1993

Interactions of Porphyromonas gingivalis with epithelial cells.

M J Duncan 1, S Nakao 1, Z Skobe 1, H Xie 1
PMCID: PMC280837  PMID: 8386706

Abstract

The invasion of gingival epithelial cells by certain pathogenic periodontal bacteria may account for their presence within diseased gingival tissue. To dissect the initial steps of a potential invasion pathway for the periodontal pathogen Porphyromonas gingivalis, laboratory and clinical bacterial isolates were tested for their interactions with a human oral epithelial cell line (KB). Several P. gingivalis strains immobilized on filters could bind oral epithelial cells. Quantitative adherence assays supported these results. The invasion of epithelial cells by P. gingivalis 33277 was measured by assay and confirmed by transmission electron microscopy. These preliminary results demonstrate that certain P. gingivalis strains are capable of internalization by human oral epithelial cells in vitro.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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