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. 1993 May;61(5):2266–2269. doi: 10.1128/iai.61.5.2266-2269.1993

TH1 and TH2 T-cell subsets are differentially activated by macrophages and B cells in murine leishmaniasis.

B Rossi-Bergmann 1, I Müller 1, E B Godinho 1
PMCID: PMC280838  PMID: 8478122

Abstract

The role of antigen-presenting cells in the differential expansion of TH1 and TH2 T cells in murine leishmaniasis was investigated. In general, macrophages preferentially induced gamma interferon and interleukin-2 secretion by syngeneic Leishmania-specific T cells, whereas B cells were more efficient in activating interleukin 4 production. B cells from susceptible BALB/c mice were better in inducing TH2 responses than B cells from resistant C57BL/6 mice, whereas macrophages from C57BL/6 mice were superior to BALB/c macrophages in inducing TH1 responses.

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Selected References

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