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. 1993 Jun;61(6):2737–2740. doi: 10.1128/iai.61.6.2737-2740.1993

Production of interleukin-6 by human and murine mononuclear leukocytes stimulated with Plasmodium antigens is enhanced by pentoxifylline, and tumor necrosis factor secretion is reduced.

J Prada 1, C Prager 1, S Neifer 1, U Bienzle 1, P G Kremsner 1
PMCID: PMC280911  PMID: 8500916

Abstract

When pentoxifylline was present during stimulation of human mononuclear leukocytes with Plasmodium falciparum exogenous antigens, an increase in interleukin-6 production was observed simultaneously with a reduction of tumor necrosis factor secretion. Similar results were obtained in murine macrophages stimulated with P. vinckei antigens. This indicates the independence of interleukin-6 and tumor necrosis factor secretion in response to malaria antigens.

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Selected References

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