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CGRP-stimulated cAMP responses of the mutated receptors where there is a decrease in potency. (a) I41A, (b) Q45A, (c) C48A and (d) Y49A. Cos-7 cells were transfected with WT/RAMP1 or mutant/RAMP1 and assayed for CGRP-stimulated cAMP production. WT type receptors; open squares. Mutant receptors; as indicated. Data are representative of three to five similar experiments.
