TABLE 6.
Association of rs10810632 (BNC2) with complications in the DCCT/EDIC
| Outcome | Conventional |
Intensive |
||
|---|---|---|---|---|
| OR or HR (95% CI) | P | OR or HR (95% CI) | P | |
| Hypoglycemia | ||||
| Requiring medical assistance | 0.49 (0.30–0.80) | 0.004 | 1.02 (0.70–1.47) | 0.94 |
| Resulting in coma/seizure | 0.60 (0.32–1.10) | 0.10 | 0.89 (0.60–1.33) | 0.58 |
| Retinopathy | ||||
| Mild nonproliferative retinopathy | 1.73 (1.31–2.27) | 0.0002 | 1.02 (0.77–1.35) | 0.90 |
| Severe nonproliferative retinopathy | 1.83 (1.29–2.62) | 0.002 | 0.61 (0.3–1.25) | 0.15 |
| Clinically significant macular edema | 1.87 (1.31–2.67) | 0.001 | 0.97 (0.56–1.69) | 0.92 |
| Nephropathy | ||||
| Persistent microalbuminuria | 1.84 (1.31–2.59) | 0.001 | 0.80 (0.46–1.41) | 0.43 |
| Severe nephropathy | 1.85 (1.19–2.87) | 0.01 | 0.32 (0.08–1.31) | 0.06 |
| Coronary calcium (β ± SE) | 0.64 ± 0.62 | 0.30 | 1.34 ± 0.57 | 0.02 |
| Confirmed clinical neuropathy | 1.64 (1.00–2.68) | 0.05 | 0.69 (0.40–1.20) | 0.6 |
See legend to Table 5. Additive coding of genotype, with the direction expressed as the number of copies of the C alleles (compared with the T allele).