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. 1993 Aug;61(8):3530–3532. doi: 10.1128/iai.61.8.3530-3532.1993

Enhancement of susceptibility of CB-17 mice to systemic candidiasis by poly(I . C)-induced interferon.

J Jensen 1, E Balish 1
PMCID: PMC281033  PMID: 8335384

Abstract

Poly(I . C) enhanced the susceptibility of CB-17 (BALB/c) mice to acute systemic candidiasis. Poly(I . C), supernatants from poly(I . C)-treated macrophages, or alpha and beta interferons suppressed macrophage candidacidal activity in vitro. Thus, poly(I . C)-induced interferons may enhance the susceptibility of CB-17 mice to candidiasis by suppressing macrophage candidacidal activity in an autocrine fashion.

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Selected References

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