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. 1993 Sep;61(9):3985–3987. doi: 10.1128/iai.61.9.3985-3987.1993

Fibroblast-stimulating factor 1, a novel lymphokine produced in schistosomal egg granulomas, stimulates liver fat-storing cells in vitro.

P Greenwel 1, D J Wyler 1, M Rojkind 1, S Prakash 1
PMCID: PMC281104  PMID: 8359921

Abstract

We report that the novel lymphokine fibroblast-stimulating factor 1, produced within hepatic schistosomal egg granulomas, stimulates liver fat-storing cells (FSC) in vitro to proliferate and express fibronectin genes. Because FSC are critical in hepatic fibrogenesis generally, we propose that in vivo stimulation of FSC by fibroblast-stimulating factor 1 may be an important step in schistosomal liver fibrosis.

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Selected References

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