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. 1993 Sep;61(9):4013–4016. doi: 10.1128/iai.61.9.4013-4016.1993

Staphylococcus-mediated T-cell activation and spontaneous natural killer cell activity in the absence of major histocompatibility complex class II molecules.

S K Chapes 1, S M Hoynowski 1, K M Woods 1, J W Armstrong 1, A A Beharka 1, J J Iandolo 1
PMCID: PMC281111  PMID: 8359928

Abstract

We used major histocompatibility complex class II antigen-deficient transgenic mice to show that in vitro natural killer cell cytotoxicity and T-cell activation by staphylococcal exotoxins (superantigens) are not dependent upon the presence of major histocompatibility complex class II molecules. T cells can be activated by exotoxins in the presence of exogenously added interleukin 1 or 2 or in the presence of specific antibody without exogenously added cytokines.

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Selected References

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