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. 1993 Oct;61(10):4498–4500. doi: 10.1128/iai.61.10.4498-4500.1993

Isotypic analysis of Plasmodium falciparum-specific antibodies and their relation to protection in Madagascar.

B Dubois 1, P Deloron 1, P Astagneau 1, C Chougnet 1, J P Lepers 1
PMCID: PMC281187  PMID: 7691751

Abstract

We previously reported that antibodies to the central repeat (DDEHVEEPTVA) of Pf155/RESA, a major Plasmodium falciparum antigen, were negatively related to antimalarial protection. We measured levels of isotype antibodies to this epitope and to P. falciparum in 76 Madagascan subjects. Immunoglobulin G (IgG) and isotype antibodies specific for P. falciparum had similar levels in individuals who were considered protected and those who were not (as determined during a longitudinal follow-up). The levels of IgG1 antibodies to (DDEHVEEPTVA)3 were higher in nonprotected subjects. The levels of total IgG and of other isotype antibodies had a similar tendency to be higher in nonprotected than in protected individuals.

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Selected References

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