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. 1993 Nov;61(11):4622–4628. doi: 10.1128/iai.61.11.4622-4628.1993

Expression of monocyte chemoattractant protein 1 in human inflamed gingival tissues.

X Yu 1, H N Antoniades 1, D T Graves 1
PMCID: PMC281213  PMID: 8406859

Abstract

Gingival inflammation is initiated by bacterial colonization on the tooth surface. It is characterized by infiltration of mononuclear cells, a common feature of many forms of chronic inflammation. Monocyte chemoattractant protein 1 (MCP-1) is the predominant monocyte chemoattractant secreted by a variety of different cells in vitro. For this report, we examined MCP-1 expression in bacterially induced gingival inflammation by immunohistochemistry and in situ hybridization. The cell types expressing MCP-1 are identified as vascular endothelial cells and monocytes/macrophages. Correlation analysis shows that the number of cells expressing MCP-1 is related to the degree of inflammation. Our finding that MCP-1 is expressed in inflamed gingival tissue suggests that MCP-1 plays an important role in the recruitment of monocytes and amplification of inflammatory signals in bacterially induced inflammation.

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Selected References

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