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Infection and Immunity logoLink to Infection and Immunity
. 1993 Apr;61(4):1544–1546. doi: 10.1128/iai.61.4.1544-1546.1993

Prolonged inhibition of bacterial protein synthesis abolishes Salmonella invasion.

K J MacBeth 1, C A Lee 1
PMCID: PMC281398  PMID: 8454361

Abstract

We have found that prolonged inhibition of bacterial protein synthesis abolishes the ability of Salmonella typhimurium to enter HEp-2 cells. Our results suggest that an essential invasion factor has a functional half-life that is seen as a gradual loss of invasiveness in the absence of protein synthesis. Therefore, Salmonella invasiveness appears to be a transient phenotype that is lost unless protein synthesis is maintained. This finding may explain why salmonellae grown to stationary phase lose their ability to enter cultured cells. In addition, a short-lived capacity to enter cells may be important during infection so that bacterial invasiveness is limited to certain times and host sites during pathogenesis.

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Selected References

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