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. 1993 Apr;61(4):1586–1588. doi: 10.1128/iai.61.4.1586-1588.1993

Exacerbation of Pneumocystis carinii pneumonia in immunodeficient (scid) mice by concurrent infection with a pneumovirus.

M V Bray 1, S W Barthold 1, C L Sidman 1, J Roths 1, A L Smith 1
PMCID: PMC281407  PMID: 8454368

Abstract

scid mice naturally infected with Pneumocystis carinii and inoculated with a normally apathogenic pneumovirus had significantly higher P. carinii cyst counts and developed significantly more severe P. carinii-related disease than did sham-inoculated, P. carinii-infected scid mice. P. carinii-free, virus-infected scid mice survived for 2 months despite high pulmonary virus titers. These results show that a respiratory virus infection can exacerbate P. carinii disease in an immunocompromised-rodent model.

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Selected References

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