Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1993 Apr;61(4):1593–1595. doi: 10.1128/iai.61.4.1593-1595.1993

Reduction of bacterial titers by low-dose aspirin in experimental aortic valve endocarditis.

D P Nicolau 1, C D Freeman 1, C H Nightingale 1, R Quintiliani 1, C J Coe 1, E G Maderazo 1, B W Cooper 1
PMCID: PMC281409  PMID: 8454370

Abstract

Using a rabbit model of Staphylococcus aureus endocarditis, we studied the effects of aspirin on the natural progression of this infection. Compared with untreated animals, the aspirin-treated animals showed a 30% (P = 0.11) reduction in the weight of the vegetations and an 84% (P = 0.03) reduction in the bacterial titer of the vegetations.

Full text

PDF
1593

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Archer G., Fekety F. R. Experimental endocarditis due to Pseudomonas aeruginosa. I. Description of a model. J Infect Dis. 1976 Jul;134(1):1–7. doi: 10.1093/infdis/134.1.1. [DOI] [PubMed] [Google Scholar]
  2. Clawson C. C., White J. G. Platelet interaction with bacteria. I. Reaction phases and effects of inhibitors. Am J Pathol. 1971 Nov;65(2):367–380. [PMC free article] [PubMed] [Google Scholar]
  3. Durack D. T., Beeson P. B. Experimental bacterial endocarditis. I. Colonization of a sterile vegetation. Br J Exp Pathol. 1972 Feb;53(1):44–49. [PMC free article] [PubMed] [Google Scholar]
  4. Durack D. T., Beeson P. B., Petersdorf R. G. Experimental bacterial endocarditis. 3. Production and progress of the disease in rabbits. Br J Exp Pathol. 1973 Apr;54(2):142–151. [PMC free article] [PubMed] [Google Scholar]
  5. Ellis E. F., Wright K. F., Jones P. S., Richardson D. W., Ellis C. K. Effect of oral aspirin dose on platelet aggregation and vascular prostacyclin (PGI2) synthesis in humans and rabbits. J Cardiovasc Pharmacol. 1980 Jul-Aug;2(4):387–397. doi: 10.1097/00005344-198007000-00006. [DOI] [PubMed] [Google Scholar]
  6. Garrison P. K., Freedman L. R. Experimental endocarditis I. Staphylococcal endocarditis in rabbits resulting from placement of a polyethylene catheter in the right side of the heart. Yale J Biol Med. 1970 Jun;42(6):394–410. [PMC free article] [PubMed] [Google Scholar]
  7. Hamill R. J. Role of fibronectin in infective endocarditis. Rev Infect Dis. 1987 Jul-Aug;9 (Suppl 4):S360–S371. doi: 10.1093/clinids/9.supplement_4.s360. [DOI] [PubMed] [Google Scholar]
  8. Herrmann M., Suchard S. J., Boxer L. A., Waldvogel F. A., Lew P. D. Thrombospondin binds to Staphylococcus aureus and promotes staphylococcal adherence to surfaces. Infect Immun. 1991 Jan;59(1):279–288. doi: 10.1128/iai.59.1.279-288.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kessler C. M., Nussbaum E., Tuazon C. U. In vitro correlation of platelet aggregation with occurrence of disseminated intravascular coagulation and subacute bacterial endocarditis. J Lab Clin Med. 1987 Jun;109(6):647–652. [PubMed] [Google Scholar]
  10. Levison M. E., Carrizosa J., Tanphaichitra D., Schick P. K., Rubin W. Effect of aspirin on thrombogenesis and on production of experimental aortic valvular Streptococcus viridans endocarditis in rabbits. Blood. 1977 Apr;49(4):645–650. [PubMed] [Google Scholar]
  11. Mason W. D. Comparative aspirin absorption kinetics after administration of sodium- and potassium-containing buffered solutions. J Pharm Sci. 1984 Jul;73(7):998–999. doi: 10.1002/jps.2600730737. [DOI] [PubMed] [Google Scholar]
  12. Miceli J. N., Aravind M. K., Cohen S. N., Done A. K. Simultaneous measurements of acetaminophen and salicylate in plasma by liquid chromatography. Clin Chem. 1979 Jun;25(6):1002–1004. [PubMed] [Google Scholar]
  13. Parkin J. D. The enigma of aspirin. Aust N Z J Med. 1987 Apr;17(2):192–194. doi: 10.1111/j.1445-5994.1987.tb00039.x. [DOI] [PubMed] [Google Scholar]
  14. Perlman B. B., Freedman L. R. Experimental endocarditis. II. Staphylococcal infection of the aortic valve following placement of a polyethylene catheter in the left side of the heart. Yale J Biol Med. 1971 Oct;44(2):206–213. [PMC free article] [PubMed] [Google Scholar]
  15. Pujadas R., Escrivá E., Fernández F., Jané J., Argimón J., Fava P., Galera M. C. Efecto de diversas dosis de aspirina sobre el desarrollo de la endocarditis trombótica aséptica aórtica inducida experimentalmente en el conejo. Rev Esp Cardiol. 1988 Jan;41(1):31–34. [PubMed] [Google Scholar]
  16. Smith J. B., Willis A. L. Aspirin selectively inhibits prostaglandin production in human platelets. Nat New Biol. 1971 Jun 23;231(25):235–237. doi: 10.1038/newbio231235a0. [DOI] [PubMed] [Google Scholar]
  17. Taylor M. L., Misso N. L., Stewart G. A., Thompson P. J. The effects of varying doses of aspirin on human platelet activation induced by PAF, collagen and arachidonic acid. Br J Clin Pharmacol. 1992 Jan;33(1):25–31. doi: 10.1111/j.1365-2125.1992.tb03996.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES