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. 1979 Mar;43(1):27–41. doi: 10.1128/mr.43.1.27-41.1979

The search for guanosine tetraphosphate (ppGpp) and other unusual nucleotides in eucaryotes.

R H Silverman, A G Atherly
PMCID: PMC281460  PMID: 379576

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adams D. G., Phillips D. O., Nichols J. M., Carr N. G. The presence and absence of magic spot nucleotide modulation in cyanobacteria undergoing nutritional shift-down. FEBS Lett. 1977 Sep 1;81(1):48–52. doi: 10.1016/0014-5793(77)80925-3. [DOI] [PubMed] [Google Scholar]
  2. Alberghina F. A., Schiaffonati L., Zardi L., Sturani E. Lack of guanosine tetraphosphate accumulation during inhibition of RNA synthesis in Neurospora crassa. Biochim Biophys Acta. 1973 Jun 23;312(2):435–439. doi: 10.1016/0005-2787(73)90389-4. [DOI] [PubMed] [Google Scholar]
  3. Baglioni C., Minks M. A., Maroney P. A. Interferon action may be mediated by activation of a nuclease by pppA2'p5'A2'p5'A. Nature. 1978 Jun 22;273(5664):684–687. doi: 10.1038/273684a0. [DOI] [PubMed] [Google Scholar]
  4. Ball L. A., White C. N. Oligonucleotide inhibitor of protein synthesis made in extracts of interferon-treated chick embryo cells: comparison with the mouse low molecular weight inhibitor. Proc Natl Acad Sci U S A. 1978 Mar;75(3):1167–1171. doi: 10.1073/pnas.75.3.1167. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Beres L., Lucas-Lenard J. Studies on the in vitro synthesis of ppGpp and pppGpp. Biochim Biophys Acta. 1975 Jun 2;395(1):80–90. doi: 10.1016/0005-2787(75)90236-1. [DOI] [PubMed] [Google Scholar]
  6. Brandhorst B., Fromson D. Lack of accumulation of ppGpp in sea urchin embryos. Dev Biol. 1976 Feb;48(2):458–460. doi: 10.1016/0012-1606(76)90107-x. [DOI] [PubMed] [Google Scholar]
  7. Buckel P., Böck A. Lack of accumulation of unusual guanosine nucleotides upon amino acid starvation of two eukaryotic organisms. Biochim Biophys Acta. 1973 Sep 28;324(1):184–187. doi: 10.1016/0005-2787(73)90262-1. [DOI] [PubMed] [Google Scholar]
  8. Cashel M., Gallant J. Two compounds implicated in the function of the RC gene of Escherichia coli. Nature. 1969 Mar 1;221(5183):838–841. doi: 10.1038/221838a0. [DOI] [PubMed] [Google Scholar]
  9. Cashel M. Regulation of bacterial ppGpp and pppGpp. Annu Rev Microbiol. 1975;29:301–318. doi: 10.1146/annurev.mi.29.100175.001505. [DOI] [PubMed] [Google Scholar]
  10. Cashel M. The control of ribonucleic acid synthesis in Escherichia coli. IV. Relevance of unusual phosphorylated compounds from amino acid-starved stringent strains. J Biol Chem. 1969 Jun 25;244(12):3133–3141. [PubMed] [Google Scholar]
  11. Chu F., Caldwell P., Weissbach H., Brot N. mRNA-dependent in vitro synthesis of ribosomal proteins L12 and L10 and elongation factor Tu. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5387–5391. doi: 10.1073/pnas.74.12.5387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Clegg J. S., Warner A. H., Finamore F. J. Evidence for the function of P-1, P-4-diguanosine 5'-tetraphosphate in the development of Artemia salina. J Biol Chem. 1967 Apr 25;242(8):1938–1943. [PubMed] [Google Scholar]
  13. Eccleston E. D., Jr, Gray E. D. Variations in ppGpp levels in Rhodopseudomonas spheroides during adaptation to decreased light intensity. Biochem Biophys Res Commun. 1973 Oct 15;54(4):1370–1376. doi: 10.1016/0006-291x(73)91138-8. [DOI] [PubMed] [Google Scholar]
  14. FINAMORE F. J., WARNER A. H. The occurrence of P1, P4-diguanosine 5'-tetraphosphate in brine shrimp eggs. J Biol Chem. 1963 Jan;238:344–348. [PubMed] [Google Scholar]
  15. Fan K., Fisher K. M., Edlin G. Effect of amino acid and serum deprivation on the regulation of RNA synthesis in cultured Chinese hamster ovary cells. Exp Cell Res. 1973 Nov;82(1):111–118. doi: 10.1016/0014-4827(73)90251-6. [DOI] [PubMed] [Google Scholar]
  16. Farrell P. J., Sen G. C., Dubois M. F., Ratner L., Slattery E., Lengyel P. Interferon action: two distinct pathways for inhibition of protein synthesis by double-stranded RNA. Proc Natl Acad Sci U S A. 1978 Dec;75(12):5893–5897. doi: 10.1073/pnas.75.12.5893. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Fiil N. P., Willumsen B. M., Friesen J. D., von Meyenburg K. Interaction of alleles of the relA, relC and spoT genes in Escherichia coli: analysis of the interconversion of GTP, ppGpp and pppGpp. Mol Gen Genet. 1977 Jan 7;150(1):87–101. doi: 10.1007/BF02425329. [DOI] [PubMed] [Google Scholar]
  18. Fortnagel P., Bergmann R. The synthesis of MS 1 and MS 2 by Bacillus subtilis. Biochem Biophys Res Commun. 1974 Jan;56(1):264–272. doi: 10.1016/s0006-291x(74)80343-8. [DOI] [PubMed] [Google Scholar]
  19. Friedman R. M. Antiviral activity of interferons. Bacteriol Rev. 1977 Sep;41(3):543–567. doi: 10.1128/br.41.3.543-567.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Furuichi Y., LaFiandra A., Shatkin A. J. 5'-Terminal structure and mRNA stability. Nature. 1977 Mar 17;266(5599):235–239. doi: 10.1038/266235a0. [DOI] [PubMed] [Google Scholar]
  21. GARDNER J. A., HOAGLAND M. B. THE ISOLATION OF GUANOSINE TETRAPHOSPHATE FROM COMMERCIALLY AVAILABLE PREPARATIONS OF GUANOSINE TRIPHOSPHATE. J Biol Chem. 1965 Mar;240:1244–1246. [PubMed] [Google Scholar]
  22. Gallant J., Margason G. Amino acid control of messenger ribonucleic acid synthesis in Bacillus subtilis. J Biol Chem. 1972 Apr 25;247(8):2289–2294. [PubMed] [Google Scholar]
  23. Gallant J., Shell L., Bittner R. A novel nucleotide implicated in the response of E. coli to energy source downshift. Cell. 1976 Jan;7(1):75–84. doi: 10.1016/0092-8674(76)90257-9. [DOI] [PubMed] [Google Scholar]
  24. Gilmour S. J., Warner A. H. The presence of guanosine 5'-diphospho-5'-guanosine and guanosine 5'-triphospho-5'-adenosine in brine shrimp embryos. J Biol Chem. 1978 Jul 25;253(14):4960–4965. [PubMed] [Google Scholar]
  25. Goh S. H., Léjohn H. B. Genetical and biochemical evidence that a novel dinucleoside polyphosphate coordinates salvage and de novo nucleotide biosynthetic pathways in mammalian cells. Biochem Biophys Res Commun. 1977 Jan 10;74(1):256–264. doi: 10.1016/0006-291x(77)91402-4. [DOI] [PubMed] [Google Scholar]
  26. Goh S. H., Wright J. A., LéJohn H. B. Possible regulation of macromolecular biosynthesis in mammalian cells by a novel dinucleoside polyphosphate (HS3) produced during step-down growth conditions. J Cell Physiol. 1977 Dec;93(3):353–362. doi: 10.1002/jcp.1040930306. [DOI] [PubMed] [Google Scholar]
  27. Griffin J. B., Davidian N. M., Penniall R. Studies of phosphorus metabolism by isolated nuclei. VII. Identification of polyphosphate as a product. J Biol Chem. 1965 Nov;240(11):4427–4434. [PubMed] [Google Scholar]
  28. Grummt F. Diadenosine 5',5'''-P1,P4-tetraphosphate triggers initiation of in vitro DNA replication in baby hamster kidney cells. Proc Natl Acad Sci U S A. 1978 Jan;75(1):371–375. doi: 10.1073/pnas.75.1.371. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Harold F. M. Inorganic polyphosphates in biology: structure, metabolism, and function. Bacteriol Rev. 1966 Dec;30(4):772–794. doi: 10.1128/br.30.4.772-794.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Heizmann P., Howell S. H. Synthesis of ppGpp and chloroplast ribosomal RNA in Chlamydomonas reinhardi. Biochim Biophys Acta. 1978 Jan 26;517(1):115–124. doi: 10.1016/0005-2787(78)90039-4. [DOI] [PubMed] [Google Scholar]
  31. Heizmann P. Rôle des synthèses protéiques dans la formation du ribosome chloroplastique chez l'Euglène. Biochimie. 1974;56(10):1357–1364. [PubMed] [Google Scholar]
  32. Heldt H. W., Klingenberg M. Endogenous nucleotides of mitochondria participating in phosphate transfer reactions as studied with 32P labelled orthophosphate and ultramicro scale ion exchange chromatography. Biochem Z. 1965 Dec 31;343(4):433–451. [PubMed] [Google Scholar]
  33. Hershko A., Mamont P., Shields R., Tomkins G. M. "Pleiotypic response". Nat New Biol. 1971 Aug;232(33):206–211. [PubMed] [Google Scholar]
  34. Horváth I., Zabos P., Szabados G., Bauer P. In vitro synthesis of guanosine polyphosphates in rat liver mitochondrial preparations. FEBS Lett. 1975 Aug 1;56(1):179–183. doi: 10.1016/0014-5793(75)80136-0. [DOI] [PubMed] [Google Scholar]
  35. Hovanessian A. G., Brown R. E., Kerr I. M. Synthesis of low molecular weight inhibitor of protein synthesis with enzyme from interferon-treated cells. Nature. 1977 Aug 11;268(5620):537–540. doi: 10.1038/268537a0. [DOI] [PubMed] [Google Scholar]
  36. Hovanessian A. G., Kerr I. M. Synthesis of an oligonucleotide inhibitor of protein synthesis in rabbit reticulocyte lysates analogous to that formed in extracts from interferon-treated cells. Eur J Biochem. 1978 Mar;84(1):149–159. doi: 10.1111/j.1432-1033.1978.tb12151.x. [DOI] [PubMed] [Google Scholar]
  37. Irr J. D., Kaulenas M. S., Unsworth B. R. Synthesis of ppGpp by mouse embryonic ribosomes. Cell. 1974 Nov;3(3):249–253. doi: 10.1016/0092-8674(74)90139-1. [DOI] [PubMed] [Google Scholar]
  38. Jacobson A., Lodish H. F. Genetic control of development of the cellular slime mold, Dictyostelium discoideum. Annu Rev Genet. 1975;9:145–185. doi: 10.1146/annurev.ge.09.120175.001045. [DOI] [PubMed] [Google Scholar]
  39. Kerr I. M., Brown R. E., Hovanessian A. G. Nature of inhibitor of cell-free protein synthesis formed in response to interferon and double-stranded RNA. Nature. 1977 Aug 11;268(5620):540–542. doi: 10.1038/268540a0. [DOI] [PubMed] [Google Scholar]
  40. Kerr I. M., Brown R. E. pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells. Proc Natl Acad Sci U S A. 1978 Jan;75(1):256–260. doi: 10.1073/pnas.75.1.256. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Klassen G. R., Furness R. A., Loewen P. C. Inhibition of E. coli DNA dependent RNA polymerase by novel nucleotides, DSI and DSII. Biochem Biophys Res Commun. 1976 Oct 4;72(3):1056–1062. doi: 10.1016/s0006-291x(76)80239-2. [DOI] [PubMed] [Google Scholar]
  42. Kudrna R., Edlin G. Nucleotide pools and regulation of ribonucleic acid synthesis in yeast. J Bacteriol. 1975 Feb;121(2):740–742. doi: 10.1128/jb.121.2.740-742.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Lewis J. A., Falcoff E., Falcoff R. Dual action of double-stranded RNA inhibiting protein synthesis in extracts of interferon-treated mouse L cells. Translation is impaired at the level of initiation and by mRNA degradation. Eur J Biochem. 1978 May 16;86(2):497–509. doi: 10.1111/j.1432-1033.1978.tb12333.x. [DOI] [PubMed] [Google Scholar]
  44. Lewis W. H., McNaughton D. R., Goh S. H., LéJohn H. B., Wright J. A. Inhibition of mammalian ribonucleotide reductase by a dinucleotide produced in eucaryotic cells. J Cell Physiol. 1977 Dec;93(3):345–352. doi: 10.1002/jcp.1040930305. [DOI] [PubMed] [Google Scholar]
  45. Lewis W. H., McNaughton D. R., LéJohn H. B., Wright J. A. Regulation of fungal ribonucleotide reductase by unusual dinucleotides. Biochem Biophys Res Commun. 1976 Jul 12;71(1):128–135. doi: 10.1016/0006-291x(76)90258-8. [DOI] [PubMed] [Google Scholar]
  46. Lindahl L., Post L., Nomura M. DNA-dependent in vitro synthesis of fibosomal proteins, protein elongation factors, and RNA polymerase subunit alpha: inhibition by ppGpp. Cell. 1976 Nov;9(3):439–448. doi: 10.1016/0092-8674(76)90089-1. [DOI] [PubMed] [Google Scholar]
  47. Lipmann F., Sy J. The enzymic mechanism of guanosine 5',3'-polyphosphate synthesis. Prog Nucleic Acid Res Mol Biol. 1976;17:1–14. doi: 10.1016/s0079-6603(08)60063-x. [DOI] [PubMed] [Google Scholar]
  48. Lobatón C. D., Vallejo C. G., Sillero A., Sillero M. A. Diguanosinetetraphosphatase from rat liver: Acitivity on diadenosine tetraphosphate and inhibition by adenosine tetraphosphate. Eur J Biochem. 1975 Jan 15;50(3):495–501. doi: 10.1111/j.1432-1033.1975.tb09888.x. [DOI] [PubMed] [Google Scholar]
  49. Loewen P. C. Novel nucleotides from E. coli isolated and partially characterized. Biochem Biophys Res Commun. 1976 Jun 21;70(4):1210–1218. doi: 10.1016/0006-291x(76)91031-7. [DOI] [PubMed] [Google Scholar]
  50. Lowdon M., Vitols E. Ribonucleotide reductase activity during the cell cycle of Saccharomyces cerevisiae. Arch Biochem Biophys. 1973 Sep;158(1):177–184. doi: 10.1016/0003-9861(73)90611-5. [DOI] [PubMed] [Google Scholar]
  51. LéJohn H. B., Cameron L. E., McNaughton D. R., Klassen G. R. Diguanosine nucleotides of fungi that regulate RNA polymerases isolated and partially characterised. Biochem Biophys Res Commun. 1975 Sep 16;66(2):460–467. doi: 10.1016/0006-291x(75)90533-1. [DOI] [PubMed] [Google Scholar]
  52. MARRIAN D. H. A new adenine nucleotide. Biochim Biophys Acta. 1953 Nov;12(3):492–492. doi: 10.1016/0006-3002(53)90176-0. [DOI] [PubMed] [Google Scholar]
  53. MARRIAN D. H. A new adenine nucleotide. Biochim Biophys Acta. 1954 Feb;13(2):278–281. doi: 10.1016/0006-3002(54)90314-5. [DOI] [PubMed] [Google Scholar]
  54. Mamont P., Hershko A., Kram R., Schacter L., Lust J., Tomkins G. M. The pleiotypic response in mammalian cells: search for an intracellular mediator. Biochem Biophys Res Commun. 1972 Sep 26;48(6):1378–1384. doi: 10.1016/0006-291x(72)90865-0. [DOI] [PubMed] [Google Scholar]
  55. Mann N., Carr N. G., Midgley J. E. RNA synthesis and the accumulation of guanine nucleotides during growth shift down in the blue-green alga Anacystis nidulans. Biochim Biophys Acta. 1975 Aug 6;402(1):41–50. doi: 10.1016/0005-2787(75)90368-8. [DOI] [PubMed] [Google Scholar]
  56. Martini O., Irr J., Richter D. Questioning of reported evidence for guanosine tetraphosphate synthesis in a ribosome system from mouse embryos. Cell. 1977 Dec;12(4):1127–1131. doi: 10.1016/0092-8674(77)90175-1. [DOI] [PubMed] [Google Scholar]
  57. Martini O., Richter D. Eukaryotic ribosomal proteins stimulate Escherichia coli stringent factor to synthesize guanosine 5'-diphosphate, 3'-diphosphate (ppGpp) and guanosine 5'-triphosphate, 3'-diphosphate (ppGpp). Mol Gen Genet. 1978 Nov 9;166(3):291–297. doi: 10.1007/BF00267621. [DOI] [PubMed] [Google Scholar]
  58. McMahon D., Langstroth P. The effects of canavanine and of arginine starvation on macromolecular synthesis in Chlamydomonas reinhardi. J Gen Microbiol. 1972 Nov;73(2):239–250. doi: 10.1099/00221287-73-2-239. [DOI] [PubMed] [Google Scholar]
  59. McNaughton D. R., Klassen G. R., LéJohn H. B. Phosphorylated guanosine derivatives of eukaryotes: regulation of DNA-dependent RNA polymerases I, II, and III in fungal development. Biochem Biophys Res Commun. 1975 Sep 16;66(2):468–474. doi: 10.1016/0006-291x(75)90534-3. [DOI] [PubMed] [Google Scholar]
  60. Oikawa T. G., Smith M. Nucleotides in the encysted embryos of Daphnia magna. Biochemistry. 1966 May;5(5):1517–1521. doi: 10.1021/bi00869a010. [DOI] [PubMed] [Google Scholar]
  61. Oki T., Yoshimoto A., Ogasawara T., Sato S., Takamatsu A. Occurrence of pppApp-synthesizing activity in actinomycetes and isolation of purine nucleotide pyrophosphotransferase. Arch Microbiol. 1976 Mar 19;107(2):183–187. doi: 10.1007/BF00446837. [DOI] [PubMed] [Google Scholar]
  62. Pao C. C., Paietta J., Gallant J. A. Synthesis of guanosine tetraphosphate (magic spot I) in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 1977 Jan 10;74(1):314–322. doi: 10.1016/0006-291x(77)91410-3. [DOI] [PubMed] [Google Scholar]
  63. Pirrone A. M., Roccheri M. C., Bellanca V., Acierno P., Giudice G. Studies on the regulation of ribosomal RNA synthesis in sea urchin development. Dev Biol. 1976 Apr;49(2):311–320. doi: 10.1016/0012-1606(76)90177-9. [DOI] [PubMed] [Google Scholar]
  64. Pollard J. W., Parker J. Guanosine tetra- and pentaphosphate synthesis by bacterial stringent factor and eukaryotic ribosomes. Nature. 1977 May 26;267(5609):371–373. doi: 10.1038/267371a0. [DOI] [PubMed] [Google Scholar]
  65. Randerath K., Janeway C. M., Stephenson M. L., Zamecnik P. C. Isolation and characterization of dinucleoside tetra- and tri-phosphates formed in the presence of lysyl-sRNA synthetase. Biochem Biophys Res Commun. 1966 Jul 6;24(1):98–105. doi: 10.1016/0006-291x(66)90416-5. [DOI] [PubMed] [Google Scholar]
  66. Rapaport E., Svihovec S. K., Zamecnik P. C. Relationship of the first step in protein synthesis to ppGpp: formation of A(5')ppp(5')Gpp. Proc Natl Acad Sci U S A. 1975 Jul;72(7):2653–2657. doi: 10.1073/pnas.72.7.2653. [DOI] [PMC free article] [PubMed] [Google Scholar]
  67. Rapaport E., Zamecnik P. C. Presence of diadenosine 5',5''' -P1, P4-tetraphosphate (Ap4A) in mamalian cells in levels varying widely with proliferative activity of the tissue: a possible positive "pleiotypic activator". Proc Natl Acad Sci U S A. 1976 Nov;73(11):3984–3988. doi: 10.1073/pnas.73.11.3984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  68. Reiness G., Yang H. L., Zubay G., Cashel M. Effects of guanosine tetraphosphate on cell-free synthesis of Escherichia coli ribosomal RNA and other gene products. Proc Natl Acad Sci U S A. 1975 Aug;72(8):2881–2885. doi: 10.1073/pnas.72.8.2881. [DOI] [PMC free article] [PubMed] [Google Scholar]
  69. Renart M. F., Renart J., Sillero M. A., Sillero A. Guanosine monophosphate reductase from Artemia salina: Inhibition by xanthosine monophosphate and activation by diguanosine tetraphosphate. Biochemistry. 1976 Nov 16;15(23):4962–4966. doi: 10.1021/bi00668a003. [DOI] [PubMed] [Google Scholar]
  70. Renart M. F., Sillero A. GMP reductase in Artemia salina. Biochim Biophys Acta. 1974 Mar 21;341(1):178–186. doi: 10.1016/0005-2744(74)90078-3. [DOI] [PubMed] [Google Scholar]
  71. Rhaese H. J., Grade R., Dichtelmüller H. Studies on the control of development. Correlation of initiucleotides in Bacillus subtilis. Eur J Biochem. 1976 Apr 15;64(1):205–213. doi: 10.1111/j.1432-1033.1976.tb10289.x. [DOI] [PubMed] [Google Scholar]
  72. Rhaese H. J., Groscurth R. Studies on the control of development. Synthesis of two highly phosphorylated nucleotides depends on changes in the composition of ribosomes at the beginning of sporulation in Bacillus subtilis. Eur J Biochem. 1978 Apr 17;85(2):517–528. doi: 10.1111/j.1432-1033.1978.tb12267.x. [DOI] [PubMed] [Google Scholar]
  73. Rhaese H. J., Hoch J. A., Groscurth R. Studies on the control of development: isolation of Bacillus subtilis mutants blocked early in sporulation and defective in synthesis of highly phosphorylated nucleotides. Proc Natl Acad Sci U S A. 1977 Mar;74(3):1125–1129. doi: 10.1073/pnas.74.3.1125. [DOI] [PMC free article] [PubMed] [Google Scholar]
  74. Rhaese H. J. Studies on the control of development synthesis of regulatory nucleotides, HPN and MS, in mammalian cells in tissue cultures. FEBS Lett. 1975 Apr 15;53(1):113–118. doi: 10.1016/0014-5793(75)80696-x. [DOI] [PubMed] [Google Scholar]
  75. Richter D. Formation of guanosine tetraphosphate (magic spot I) in homologous and heterologous systems. FEBS Lett. 1973 Aug 15;34(2):291–294. doi: 10.1016/0014-5793(73)80814-2. [DOI] [PubMed] [Google Scholar]
  76. Richter D., Isono K. A stringent factor activity associated with the 50 S ribosomal subunit of Bacillus stearothermophilus. FEBS Lett. 1974 Aug 30;44(3):270–273. doi: 10.1016/0014-5793(74)81155-5. [DOI] [PubMed] [Google Scholar]
  77. Roberts W. K., Hovanessian A., Brown R. E., Clemens M. J., Kerr I. M. Interferon-mediated protein kinase and low-molecular-weight inhibitor of protein synthesis. Nature. 1976 Dec 2;264(5585):477–480. doi: 10.1038/264477a0. [DOI] [PubMed] [Google Scholar]
  78. Roth R. M., Dampier C. Dependence of ribonucleic acid synthesis on continuous protein synthesis in yeast. J Bacteriol. 1972 Feb;109(2):773–779. doi: 10.1128/jb.109.2.773-779.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  79. SACKS J. Adenosine pentaphosphate from commercial ATP. Biochim Biophys Acta. 1955 Mar;16(3):436–436. doi: 10.1016/0006-3002(55)90253-5. [DOI] [PubMed] [Google Scholar]
  80. Shatkin A. J. Capping of eucaryotic mRNAs. Cell. 1976 Dec;9(4 Pt 2):645–653. doi: 10.1016/0092-8674(76)90128-8. [DOI] [PubMed] [Google Scholar]
  81. Shiokawa K., Kawahara A., Misumi Y., Yasuda Y., Yamana K. Inhibitor of ribosomal RNA synthesis in Xenopus laevis embryos. VI. Occurrence in mature oocytes and unfertilized eggs. Dev Biol. 1977 May;57(1):210–214. doi: 10.1016/0012-1606(77)90366-9. [DOI] [PubMed] [Google Scholar]
  82. Shiokawa K., Yamana K. Inhibitor of ribosomal RNA synthesis in Xenopus laevis embryos. IV. The release of inhibitor from cultured cells. Dev Biol. 1975 Dec;47(2):303–309. doi: 10.1016/0012-1606(75)90284-5. [DOI] [PubMed] [Google Scholar]
  83. Shulman R. W., Sripati C. E., Warner J. R. Noncoordinated transcription in the absence of protein synthesis in yeast. J Biol Chem. 1977 Feb 25;252(4):1344–1349. [PubMed] [Google Scholar]
  84. Silverman R. H., Atherly A. G. Mouse embryos fail to synthesize detectable quantities of guanosine 5'-diphosphate 3'-diphosphate. Dev Biol. 1977 Mar;56(1):200–205. doi: 10.1016/0012-1606(77)90163-4. [DOI] [PubMed] [Google Scholar]
  85. Silverman R. H., Atherly A. G. Unusual effects of 5a,6-anhydrotetracycline and other tetracyclines. Inhibition of guanosine 5'-diphosphate 3'-diphosphate metabolism, RNA accumulation and other growth-related processes in Escherichia coli. Biochim Biophys Acta. 1978 Apr 27;518(2):267–276. doi: 10.1016/0005-2787(78)90183-1. [DOI] [PubMed] [Google Scholar]
  86. Small G. D., Cooper C. Purification and properties of nucleoside tetraphosphate hydrolase from rabbit muscle. Biochemistry. 1966 Jan;5(1):14–26. doi: 10.1021/bi00865a003. [DOI] [PubMed] [Google Scholar]
  87. Small G. D., Cooper C. Studies on the occurrence and biosynthesis of adenosine tetraphosphate. Biochemistry. 1966 Jan;5(1):26–33. doi: 10.1021/bi00865a004. [DOI] [PubMed] [Google Scholar]
  88. Smulson M. Amino acid deprivation of human cells: effects on RNA synthesis, RNA polymerase, and ribonucleoside phosphorylation. Biochim Biophys Acta. 1970 Feb 18;199(2):537–540. doi: 10.1016/0005-2787(70)90100-0. [DOI] [PubMed] [Google Scholar]
  89. Sy J., Akers H. Purification and properties of guanosine 5', 3'-polyphosphate synthetase from Bacillus brevis. Biochemistry. 1976 Oct 5;15(20):4399–4403. doi: 10.1021/bi00665a008. [DOI] [PubMed] [Google Scholar]
  90. Sy J., Chua N. H., Ogawa Y., Lipmann F. Ribosome specificity for the formation of guanosine polyphosphates. Biochem Biophys Res Commun. 1974 Feb 4;56(3):611–616. doi: 10.1016/0006-291x(74)90648-2. [DOI] [PubMed] [Google Scholar]
  91. Sy J., Ogawa Y., Lipmann F. Nonribosomal synthesis of guanosine 5',3'-polyphosphates by the ribosomal wash of stringent Escherichia coli. Proc Natl Acad Sci U S A. 1973 Jul;70(7):2145–2148. doi: 10.1073/pnas.70.7.2145. [DOI] [PMC free article] [PubMed] [Google Scholar]
  92. Thammana P., Buerk R. R., Gordon J. Absence of ppGpp production in synchronised Balb/C mouse 3T3 cells on isoleucine starvation. FEBS Lett. 1976 Oct 1;68(2):187–190. doi: 10.1016/0014-5793(76)80433-4. [DOI] [PubMed] [Google Scholar]
  93. Vallejo C. G., Lobaton C. D., Quintanilla M., Sillero A., Sillero M. A. Dinucleosidasetetraphosphatase in rat liver and Artemia salina. Biochim Biophys Acta. 1976 Jun 7;438(1):304–309. doi: 10.1016/0005-2744(76)90246-1. [DOI] [PubMed] [Google Scholar]
  94. Vallejo C. G., Sillero M. A., Sillero A. Diguanosinetetraphosphate guanylohydrolase in Artemia salina. Biochim Biophys Acta. 1974 Jul 17;358(1):117–125. doi: 10.1016/0005-2744(74)90264-2. [DOI] [PubMed] [Google Scholar]
  95. Van Denbos G., Finamore F. J. An unusual pathway for the synthesis of adenosine triphosphate by the purine-requiring organism Artemia salina. J Biol Chem. 1974 May 10;249(9):2816–2818. [PubMed] [Google Scholar]
  96. Warner A. H., Beers P. C., Huang F. L. Biosynthesis of the diguanosine nucleotides. I. Purification and properties of an enzyme from yolk platelets of brine shrimp embryos. Can J Biochem. 1974 Mar;52(3):231–240. doi: 10.1139/o74-036. [DOI] [PubMed] [Google Scholar]
  97. Warner A. H., Finamore F. J. Isolation, purification, and characterization of P1,P3-diguanosine 5'-triphosphate from brine shrimp eggs. Biochim Biophys Acta. 1965 Dec 9;108(4):525–530. doi: 10.1016/0005-2787(65)90049-3. [DOI] [PubMed] [Google Scholar]
  98. Warner A. H., Finamore F. J. Isolation, purification, and characterization of P1,P4-diguanosine 5'-tetraphosphate asymmetrical-pyrophosphohydrolase from brine shrimp eggs. Biochemistry. 1965 Aug;4(8):1568–1575. doi: 10.1021/bi00884a016. [DOI] [PubMed] [Google Scholar]
  99. Warner A. H., Finamore F. J. Nucleotide metabolism during brine shrimp embryogenesis. J Biol Chem. 1967 Apr 25;242(8):1933–1937. [PubMed] [Google Scholar]
  100. Warner A. H., Huang F. L. Biosynthesis of the diguanosine nucleotides. II. Mechanism of action of GTP:GTP guanylyltransferase on nucleotide metabolism in brine shrimp embryos. Can J Biochem. 1974 Mar;52(3):241–251. doi: 10.1139/o74-037. [DOI] [PubMed] [Google Scholar]
  101. Warner A. H., McClean D. K. Studies on the biosynthesis and role of diguanosine tetraphosphate during growth and development of Artemia salina. Dev Biol. 1968 Sep;18(3):278–293. doi: 10.1016/0012-1606(68)90036-5. [DOI] [PubMed] [Google Scholar]
  102. Warner A. H., Puodziukas J. G., Finamore F. J. Yolk platelets in brine shrimp embryos. Site of biosynthesis and storage of the diguanosine nucleotides. Exp Cell Res. 1972 Feb;70(2):365–375. doi: 10.1016/0014-4827(72)90148-6. [DOI] [PubMed] [Google Scholar]
  103. Warner A. H., Thomas D. D., Shridhar V., McCurdy H. D. The diguanosine nucleotides: do they exist in aquatic fungi? Can J Biochem. 1977 Aug;55(8):841–846. doi: 10.1139/o77-124. [DOI] [PubMed] [Google Scholar]
  104. Williams B. R., Kerr I. M. Inhibition of protein synthesis by 2'-5' linked adenine oligonucleotides in intact cells. Nature. 1978 Nov 2;276(5683):88–90. doi: 10.1038/276088a0. [DOI] [PubMed] [Google Scholar]
  105. Winand-Devigne J., Hamoir G., Liébecq C. Interactions of adenosine tetraphosphate with myosin and actomyosin. Eur J Biochem. 1967 Mar;1(1):29–32. doi: 10.1007/978-3-662-25813-2_6. [DOI] [PubMed] [Google Scholar]
  106. Yamana K., Shiokawa K. Inhibitor of ribosomal RNA synthesis in Xenopus laevis embryos. V. Inability of inhibitor to repress 5S RNA synthesis. Dev Biol. 1975 Dec;47(2):461–463. doi: 10.1016/0012-1606(75)90299-7. [DOI] [PubMed] [Google Scholar]
  107. Zamecnik P. C., Stephenson M. L., Janeway C. M., Randerath K. Enzymatic synthesis of diadenosine tetraphosphate and diadenosine triphosphate with a purified lysyl-sRNA synthetase. Biochem Biophys Res Commun. 1966 Jul 6;24(1):91–97. doi: 10.1016/0006-291x(66)90415-3. [DOI] [PubMed] [Google Scholar]
  108. Zilberstein A., Kimchi A., Schmidt A., Revel M. Isolation of two interferon-induced translational inhibitors: a protein kinase and an oligo-isoadenylate synthetase. Proc Natl Acad Sci U S A. 1978 Oct;75(10):4734–4738. doi: 10.1073/pnas.75.10.4734. [DOI] [PMC free article] [PubMed] [Google Scholar]

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