An Algorithm Informed by the Parathyroid Hormone Level Reduces Hypocalcemic Complications of Thyroidectomy

Abstract

Background

Measurement of the parathyroid hormone (PTH) level following total thyroidectomy (TTx) may allow prediction of postoperative hypocalcemia. We present an algorithmic method of managing hypocalcemia pre-emptively, based on the PTH level 1 h after operation.

Materials and methods

We examined 423 consecutive patients undergoing TTx at a single institution. A subset of patients were managed using an algorithm involving routine postoperative oral calcium administration and the early addition of oral calcitriol in patients with a low 1-h postoperative PTH level. Algorithm patients were compared to a concurrent, conventionally managed group. Outcomes measured included serum calcium levels, symptoms of hypocalcemia, postoperative complications, and receipt of intravenous (IV) calcium.

Results

The algorithm was applied in 135 patients, and 288 patients were managed conventionally. Critically low calcium levels (total calcium <7.5 mg/dl [1.88 mmol/l] or ionized calcium <0.94 mmol/l) were less common in algorithm patients (10.6% vs. 25.3%; p < 0.005). Much of this difference was attributable to the protective impact of the algorithm on patients undergoing TTx for cancer, 30% of whom developed critically low calcium levels when managed conventionally. Among patients requiring IV calcium, algorithm patients received fewer doses (1.29 vs. 1.86; p < 0.05). Low 1-h PTH levels were found in 21% (28/133) of algorithm patients, but these did not correlate with low calcium levels, suggesting that the algorithm compensated adequately for temporary hypoparathyroidism. No patients developed hypercalcemia.

Conclusions

An algorithmic approach incorporating early postoperative PTH levels and routine administration of oral calcium reduces the risk of severe hypocalcemia after total thyroidectomy.

Introduction

The management of hypocalcemia after total thyroidectomy (TTx) remains a challenge. Transient hypocalcemia is one of the most common postoperative complications of TTx, occurring in 17–26% of patients, and it results from direct injury to, devascularization of, or accidental removal of the parathyroid glands [1–4]. Though early postoperative hypocalcemia is reversible in the great majority of cases, permanent hypoparathyroidism is likely much more common than previously suspected [1].

To manage postoperative hypocalcemia, most practitioners obtain serial serum calcium measurements and respond appropriately to low levels. Recently, several groups have advocated measurement of the parathyroid hormone (PTH) level several hours after operation in order to predict the development of hypocalcemia [5–13]. This practice has not been widely adopted, nor has it been incorporated into a standardized system of care for patients undergoing TTx.

In the present study, we examined the impact of a management algorithm incorporating the postoperative PTH level as a means of preempting the development of hypocalcemia after TTx.

Materials and methods

Patient selection

Data on 476 consecutive patients undergoing total thyroidectomy at UCLA Medical Center between January 2006 and December 2008 were used in this retrospective cohort study. Patients with a history of hyperparathyroidism, kidney transplantation, or renal failure were excluded, as were patients undergoing emergency operations. In addition, patients with a history of previous thyroid surgery, those with nonthyroid cancers (namely cancers invading or metastasizing to the thyroid), and those undergoing simultaneous operations on the thymus, thyroglossal duct, or radical/modified radical lymph node dissection were excluded. Using these criteria, 421 patients were included in the final study group. All subjects were over the age of 18.

An algorithm for the management of post-thyroidectomy calcium was implemented beginning on January 1, 2006 by select physicians in the Division of General Surgery (Fig. 1). This algorithm was developed at UCLA Medical Center and entails routine postoperative oral calcium supplementation for all patients, plus the early addition of calcitriol for patients with PTH levels ≤15 pg/ml (normal: 11–51 pg/ml) at 1 h after surgery. Standardized, preprinted order sheets were created for algorithm implementation, which was carried out in conjunction with education of residents, nurses, and ancillary staff to ensure compliance.

Fig. 1.

Clinical pathway for postoperative calcium management following total thyroidectomy

Data collection

Demographic data collected included age, gender, and race. Co-morbid conditions were defined using the Deyo modification [9] of the Charlson co-morbidity index, which uses International Classification of Diseases, Ninth Revision (ICD-9-CM) codes from medical records to sum the number of conditions from 17 diagnostic categories. Other variables recorded included length of stay (LOS), number of days spent in the ICU, and number of doses of intravenous (IV) calcium received. The aggregate postoperative complication rate was determined using ICD-9-CM codes for six conditions: respiratory failure, hematoma formation, recurrent laryngeal nerve injury, wound complications, and signs or symptoms of hypocalcemia. Since complications were uncommon, a dichotomous variable for presence of any complications (present/absent) was used in some analyses. For algorithm patients, a single postoperative calcium level was measured from blood drawn at 4:00 a.m. on postoperative day 1, whereas non-algorithm patients underwent serial serum calcium measurements every 6–8 h. Serum calcium levels were grouped into the following categories: normal (≥8.7 mg/dl), low (7.5–8.6 mg/dl), and critically low (<7.5 mg/dl). Ionized calcium levels (mmol/l) were converted to total calcium levels (mg/dl) by multiplying by a factor of 8. This conversion yielded an identical, consistent reference range and was valid in a normoalbuminemic patient cohort undergoing elective surgery. Finally, postoperative PTH levels, obtained routinely only in the algorithm group, were recorded and categorized as being normal (>15 pg/ml), low-normal (10–15 pg/ml), or low (<10 pg/ml).

Data analysis

Data were analyzed by Student’s t-test, contingency table analysis, or one-way analysis of variance (ANOVA) for univariate analyses. Logistic regression was applied for a multivariate analysis. Differences were considered statistically significant for p values <0.05. Data were analyzed with STATA/SE version 9.2 (StataCorp, College Station, TX).

Results

The algorithm was applied in 135 patients, and 288 patients were managed conventionally. Conventionally managed patients received calcium replacement in response to serially drawn serum calcium levels and/or clinical manifestations of hypocalcemia. Demographic characteristics of the comparison groups are shown in Table 1. Length of hospitalization was significantly shorter in the algorithm population (1.10 ± 0.48 days vs. 2.72 ± 2.1 days; p < 0.0001). When the indication for surgery was considered, non-algorithm patients were more likely to undergo surgery for thyroid cancer (56.2% vs. 45.1%; p < 0.05). Algorithm patients were less likely to have critically low calcium levels during hospitalization (Fig. 2). Of the total cases during the study period, 91% were managed by 5 surgeons, all of whom did more than 35 operations. The mean number of episodes of critical hypocalcemia was not significantly different when comparing high-volume (>35 cases) to low-volume (<35 cases) surgeons (0.229 vs. 0.230; p = 0.51). The protective impact of the algorithm was more pronounced among patients undergoing TTx for cancer, 30% of whom developed critically low calcium levels when managed conventionally. In a multivariate logistic regression controlling for age, sex, race, insurance status (Medicare vs. private), co-morbidity (excluding thyroid cancer), length of hospitalization, and thyroid cancer status, only algorithm status predicted risk of having at least one low or critically low calcium value. Specifically, non-algorithm patients had a 2.17× greater risk of having a low calcium value during hospitalization compared with algorithm patients (95% CI 1.20–3.92; p < 0.01).

Table 1.

Demographic comparison of the study samples

	Non-algorithm (n = 288)	Algorithm (n = 133)	p Value
Mean age ± SD	50.0 ± 15.3	47.6 ± 15.7	0.14
Female (%)	223 (77.4)	112 (84.2)	0.10
Race/ethnicity (%)
White	191 (66.3)	83 (62.4)	<0.05
Asian/Pacific Islander	25 (8.7)	27 (20.3)
Hispanic	26 (9.0)	10 (7.5)
Black	20 (6.9)	7 (5.3)
Native American/other	26 (9.0)	6 (4.5)
Mean Charlson co-morbidity index ± SD	0.15 ± 0.40	0.13 ± 0.54	0.64

Fig. 2.

Comparison of outcomes for all patients (a), those patients with a non-cancer diagnosis (b), and those with a cancer diagnosis (c). *p < 0.05; **p < 0.01

Non-algorithm and algorithm patients were equally likely to receive IV calcium (14.9% vs. 12.8%; NS). Among patients who received IV calcium, non-algorithm patients received a higher average number of doses (1.86 vs. 1.29; p < 0.05).

In algorithm patients, the 1-h PTH level correlated positively with the morning calcium level on postoperative day 1 (Fig. 3). Given the PTH cut-points assigned to different branches of the algorithm, we also examined the relationship between the morning calcium level and the PTH category (normal, low-normal, low; Fig. 4). Twenty-one percent (28/133) of algorithm patients had low 1-h PTH levels, of which 28.6% (8/28) developed critically low calcium levels. Sixty-one percent (81/133) had normal 1 h PTH levels, with 5% (4/81) of those individuals developing critically low serum calcium. A low postoperative PTH level predicted low (n = 45) or critically low (n = 8) postoperative calcium levels with a sensitivity of 93% and a specificity of 98%. A normal 1-h PTH was associated with higher mean calcium compared with either the low-normal or low PTH groups (p < 0.0001). Calcium values in the low versus low-normal PTH groups were not significantly different.

Fig. 3.

Scatter graph demonstrating the relationship between postoperative day 1 calcium and 1-h PTH

Fig. 4.

Scatter graph demonstrating the relationship between postoperative day 1 calcium and 1-h PTH grouped by measurement range

Discussion

The use of intraoperative or postoperative PTH levels to predict hypocalcemia following TTx remains controversial. Several groups have found that PTH levels cannot reliably predict postoperative hypocalcemia [14, 15]. Lombardi et al. [16] reported that parathyroid hormone measurements less than 10 pg/ml levels alone 4 h after surgery were unable to accurately predict hypocalcemia in 13.4% of their study population, 2.1% of whom were symptomatic. Other investigators support the use of PTH in identifying patients likely to develop hypocalcemia following thyroidectomy [5–13]. McLeod et al. [17] showed that postoperative PTH levels less than 12 pg/ml had a 100% sensitivity and 92% specificity for predicting hypocalcemia. This was corroborated by the work of Sywak et al. [18], which demonstrated a sensitivity of 90% and a specificity of 84% of PTH levels from 3–10 pg/ml drawn 4 h after surgery for predicting postoperative hypocalcemia (as defined by corrected calcium levels ≤2.0 mmol/l). Similarly, in a study looking at the experiences of five separate Australian institutions, Grodski and Serpell [19] demonstrated a sensitivity, specificity and positive predictive value of 70.7%, 92.6%, and 71.6%, respectively, for low PTH levels (<10 ng/l) 4 h after surgery in predicting postoperative hypocalcemia (<2.00 mmol/l). This led to the inclusion of the routine measurement of PTH postoperatively in the Australian Endocrine Surgeons Guidelines for patients undergoing total thyroidectomy [20]. In a 2008 meta-analysis of 27 papers, Grodski and Serpell [19] reiterated this recommendation, reporting that postoperative PTH at any time within 24 h of total thyroidectomy can be used to accurately predict the development of hypocalcemia and anticipate the need for calcium replacement, albeit with class C evidence. In this same vein, our findings support the use of PTH to identify those patients in whom postoperative hypocalcemia may be anticipated.

Our practice is to administer oral calcitriol to all patients with low and low-normal postoperative PTH levels. The efficacy of this drug treatment is supported by a number of previous studies [21–23]. Tartaglia et al. [24] showed in 2005 that oral administration of calcium and calcitriol after thyroidectomy significantly decreases the risk of postoperative hypocalcemia. Calcitriol induces a fourfold increase in the uptake of oral calcium [25], reducing by half the dosage required to maintain physiologic levels in the postoperative period. This requires less frequent dosing and alleviates much of the nausea and constipation associated with large amounts of oral calcium, ultimately leading to superior patient compliance. Additionally, since a generic form became available in 2001, calcitriol is inexpensive ($1.20 per 0.25 mcg pill, TEVA Pharmaceuticals, Petach Tikva, Israel). When used judiciously in a sliding scale fashion, calcitriol does not lead to overtreatment (to date, this practice has not resulted in any episodes of hypercalcemia in our experience). For these reasons, we emphasize the use of calcitriol in combination with lower doses of oral calcium in lieu of large doses of oral calcium alone. In a separate but related study, we found that algorithmic management results in a significantly decreased length of hospital stay, reduced costs associated with multiple lab draws, and a reduced need for IV calcium administration. Furthermore, implementation of the algorithm reduced the number of hospital readmissions for postoperative complications to zero. These combined benefits yielded an average savings of $1,631 (74%) per patient in our hospital system [26].

We noted a statistically significant difference in the percentages of patients undergoing TTx for a cancer versus non-cancer diagnosis between the two study samples. Given the need to conduct a more aggressive operation in the treatment of malignancy, we postulated that an increased frequency of postoperative hypoparathyroidism would be observed in this patient population. The hypothesis was borne out in our data, which demonstrated a greater prevalence of critically low calcium levels among patients undergoing TTx for cancer, with a rate of 30% in those managed conventionally. This increased risk was present regardless of postoperative management, suggesting that, at present, our algorithm may be not aggressive enough to prevent hypocalcemia in this patient subset. In a randomized analysis of patients undergoing TTx with central lymph node dissection for papillary cancer, Roh et al. [22] demonstrated a postoperative hypocalcemia (<8.0 mg/dl) rate of 44% in patients who received neither oral calcium supplementation nor calcitriol. This rate decreased to 24% with administration of oral calcium, and 8.2% with a combination of oral calcium and calcitriol. The implication is that patients undergoing TTx for cancer are particularly vulnerable to postoperative hypoparathyroidism and anticipatory measures should be routinely employed.

The major limitation of postoperative PTH measurement is the possibility that these values may be spuriously normal or high in a patient that subsequently develops unanticipated critically low calcium levels. Among the 133 algorithm patients in our study, 81 (61%) had normal 1-h PTH levels, and only 5% (4/81) went on to develop critically low morning calcium levels. Therefore, though we acknowledge that spuriously normal PTH levels are occasionally found, these occurrences are rare. Notably, appropriate and timely intervention was taken in all algorithm patients who ultimately required IV calcium supplementation. The routine measurement of serum calcium on the morning following operation is an additional safeguard that permits identification of patients with hypoparathyroidism, even among those not correctly identified by the postoperative PTH level. Furthermore, all patients are discharged on continued calcium supplementation for 2 weeks, regardless of inpatient lab results (a low dose of 1,000 mg calcium carbonate twice daily with no calcitriol is used for patients with completely normal PTH and calcium levels). This affords a third tier of protection against the development of hypocalcemia should it occur in a delayed fashion following discharge, thus preventing hospital readmissions.

This study is limited by its retrospective, nonrandomized design. Despite these weaknesses, our data favor implementation of an algorithmic approach to calcium management after total thyroidectomy that is informed by measurement of postoperative PTH level.