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. 1988 Aug;85(15):5434–5438. doi: 10.1073/pnas.85.15.5434

Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein.

H Fukumoto 1, S Seino 1, H Imura 1, Y Seino 1, R L Eddy 1, Y Fukushima 1, M G Byers 1, T B Shows 1, G I Bell 1
PMCID: PMC281771  PMID: 3399500

Abstract

cDNA clones encoding a glucose transporter-like protein have been isolated from adult human liver and kidney cDNA libraries by cross-hybridization with the human HepG2/erythrocyte glucose transporter cDNA. Analysis of the sequence of this 524-amino acid glucose transporter-like protein indicates that it has 55.5% identity with the HepG2/erythrocyte glucose transporter as well as a similar structural organization. Studies of the tissue distribution of the mRNA coding for this glucose transporter-like protein in adult human tissues indicate that the highest amounts are present in liver with lower amounts in kidney and small intestine. The amounts of glucose transporter-like mRNA in other tissues, including colon, stomach, cerebrum, skeletal muscle, and adipose tissue, were below the level of sensitivity of our assay. The single-copy gene encoding this glucose transporter-like protein has been localized to the q26.1----q26.3 region of chromosome 3.

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Selected References

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