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. 1988 Aug;85(15):5492–5496. doi: 10.1073/pnas.85.15.5492

Crosstalk between bacterial chemotaxis signal transduction proteins and regulators of transcription of the Ntr regulon: evidence that nitrogen assimilation and chemotaxis are controlled by a common phosphotransfer mechanism.

A J Ninfa 1, E G Ninfa 1, A N Lupas 1, A Stock 1, B Magasanik 1, J Stock 1
PMCID: PMC281783  PMID: 3041412

Abstract

We demonstrate by using purified bacterial components that the protein kinases that regulate chemotaxis and transcription of nitrogen-regulated genes, CheA and NRII, respectively, have cross-specificities: CheA can phosphorylate the Ntr transcription factor NRI and thereby activate transcription from the nitrogen-regulated glnA promoter, and NRII can phosphorylate CheY. In addition, we find that a high intracellular concentration of a highly active mutant form of NRII can suppress the smooth-swimming phenotype of a cheA mutant. These results argue strongly that sensory transduction in the Ntr and Che systems involves a common protein phosphotransfer mechanism.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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