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. 1988 Aug;85(15):5664–5668. doi: 10.1073/pnas.85.15.5664

Immunological function of HLA-C antigens in HLA-Cw3 transgenic mice.

O Dill 1, F Kievits 1, S Koch 1, P Ivanyi 1, G J Hämmerling 1
PMCID: PMC281820  PMID: 2840670

Abstract

The human major histocompatibility complex encodes three classical class I antigens, HLA-A, -B, and -C. Of these HLA-A and -B act as strong transplantation antigens and as restriction molecules for recognition of foreign antigen by cytotoxic T lymphocytes. In contrast, little is known about HLA-C and it is not clear whether HLA-C has the same functional properties as HLA-A and -B. Transgenic C57BL/6 mice expressing the HLA-Cw3 gene were established. Functional studies demonstrated that transgenic skin was rapidly rejected by normal C57BL/6 mice and that cytotoxic T lymphocytes generated by immunization of the Cw3 transgenic mice with influenza and Sendai virus were restricted by the Cw3 molecule. These data suggest that HLA-Cw3 has immunological functions comparable to those of HLA-A and -B.

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Selected References

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