Table 2.

Basic information for the top 18 pathways in the pathway-based GWA analysis for FN Z in the total U.S. whites

Entry	Pathway name	Source	Total	Male	Female
Hsa00624	1- and 2-Methylnaphthalene degradation	KEGG	< 0.001	-	0.056
Amb121	EphrinA-EphR Signaling	Ambion	< 0.001	0.006	-
GO:0051051	Negative regulation of transport	GO	< 0.001	-	-
Hsa01031	Glycan structures - biosynthesis 2	KEGG	0.002	0.035	-
StemPathway	Regulation of hematopoiesis by cytokines	BioCarta	0.003	-	-
cdc42racPathway	Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration	BioCarta	0.003	0.011	-
GO:0030097	Hemopoiesis	GO	0.004	-	0.081
Hsa00960	Alkaloid biosynthesis II	KEGG	0.004	0.002	-
Hsa04810	Regulation of actin cytoskeleton	KEGG	0.004	-	-
GO:0016776	Phosphotransferase activity, phosphate group as acceptor	GO	0.005	-	-
Amb1	14-3-3 and Cell Cycle Regulation	Ambion	0.006	-	-
GO:0016616	Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	GO	0.007	0.004	-
GO:0008285	Negative regulation of cell proliferation	GO	0.007	0.069	0.088
Amb285	PDGF Pathway	Ambion	0.007	0.053	-
Edg1Pathway	Phospholipids as signalling intermediaries	BioCarta	0.008	-	-
GO:0016799	Hydrolase activity, hydrolyzing N-glycosyl compounds	GO	0.008	0.004	-
Amb265	Oct4 in Mammalian ESC Pluripotency	Ambion	0.009	-	-
Hsa00350	Tyrosine metabolism	KEGG	0.009	0.061	-

Note: All: association results for FN Z in the total sample; Male, Female: association results for FN Z in the male and female subgroups, respectively. “-” denotes nominal p value > 0.01.