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. 1988 Aug;85(15):5723–5727. doi: 10.1073/pnas.85.15.5723

A-type potassium channels expressed from Shaker locus cDNA.

L E Iverson 1, M A Tanouye 1, H A Lester 1, N Davidson 1, B Rudy 1
PMCID: PMC281833  PMID: 2456579

Abstract

A-type K+ currents are expressed in Xenopus oocytes injected with in vitro-synthesized transcripts from cDNAs for the Drosophila Shaker (Sh) locus. A single Sh gene product, possibly as a multimer, is sufficient for formation of functional A channels. Various Sh RNAs express A currents with distinct kinetic properties. An analysis of structure-function relationships shows that the conserved central region of Sh polypeptides determines ionic selectivity and overall channel behavior, whereas the divergent amino and carboxyl termini can modify channel kinetics. Alternative splicing of Sh gene transcripts may provide one mechanism for the generation of K+ channel diversity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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