Skip to main content
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1988 Aug;85(16):5923–5926. doi: 10.1073/pnas.85.16.5923

Chemical oscillations in closed macromolecular systems.

E Di Cera 1, P E Phillipson 1, J Wyman 1
PMCID: PMC281877  PMID: 3413066

Abstract

A cycle of irreversible, first-order, autocatalytic reactions among different states of a polyfunctional macromolecule, subject to the conservation of mass, can display stable chemical oscillations. This introduces a class of nonlinear dynamic models for energy transduction in closed macromolecular systems.

Full text

PDF
5923

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cech T. R., Bass B. L. Biological catalysis by RNA. Annu Rev Biochem. 1986;55:599–629. doi: 10.1146/annurev.bi.55.070186.003123. [DOI] [PubMed] [Google Scholar]
  2. Di Cera E., Gill S. J., Wyman J. Binding capacity: cooperativity and buffering in biopolymers. Proc Natl Acad Sci U S A. 1988 Jan;85(2):449–452. doi: 10.1073/pnas.85.2.449. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Di Cera E., Gill S. J., Wyman J. Canonical formulation of linkage thermodynamics. Proc Natl Acad Sci U S A. 1988 Jul;85(14):5077–5081. doi: 10.1073/pnas.85.14.5077. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Eigen M. Selforganization of matter and the evolution of biological macromolecules. Naturwissenschaften. 1971 Oct;58(10):465–523. doi: 10.1007/BF00623322. [DOI] [PubMed] [Google Scholar]
  5. Phillipson P. E., Ackerson B. J., Wyman J. Heme proteins: effect of an intermediate on photochemical behavior. Proc Natl Acad Sci U S A. 1973 May;70(5):1550–1553. doi: 10.1073/pnas.70.5.1550. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Phillipson P. E., Schuster P., Kemler F. Dynamical machinery of a biochemical clock. Bull Math Biol. 1984;46(3):339–355. doi: 10.1007/BF02462010. [DOI] [PubMed] [Google Scholar]
  7. Slater E. C., Berden J. A., Herweijer M. A. A hypothesis for the mechanism of respiratory-chain phosphorylation not involving the electrochemical gradient of protons as obligatory intermediate. Biochim Biophys Acta. 1985 Aug 1;811(3):217–231. doi: 10.1016/0304-4173(85)90012-6. [DOI] [PubMed] [Google Scholar]
  8. Westerhoff H. V., Tsong T. Y., Chock P. B., Chen Y. D., Astumian R. D. How enzymes can capture and transmit free energy from an oscillating electric field. Proc Natl Acad Sci U S A. 1986 Jul;83(13):4734–4738. doi: 10.1073/pnas.83.13.4734. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Wyman J. Linkage graphs: a study in the thermodynamics of macromolecules. Q Rev Biophys. 1984 Nov;17(4):453–488. doi: 10.1017/s0033583500004881. [DOI] [PubMed] [Google Scholar]
  10. Wyman J. The turning wheel: a study in steady states. Proc Natl Acad Sci U S A. 1975 Oct;72(10):3983–3987. doi: 10.1073/pnas.72.10.3983. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES