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. 1988 Aug;85(16):6122–6126. doi: 10.1073/pnas.85.16.6122

Unusual lipid structures selectively reduce the toxicity of amphotericin B.

A S Janoff 1, L T Boni 1, M C Popescu 1, S R Minchey 1, P R Cullis 1, T D Madden 1, T Taraschi 1, S M Gruner 1, E Shyamsunder 1, M W Tate 1, et al.
PMCID: PMC281917  PMID: 3413081

Abstract

Ribbon-like structures result when amphotericin B interacts with lipid in an aqueous environment. At high ratios of amphotericin to lipid these structures, which are lipid-stabilized amphotericin aggregates, become prevalent resulting in a dramatic attenuation of amphotericin-mediated mammalian cell, but not fungal cell, toxicity. Studies utilizing freeze-etch electron microscopy, differential scanning calorimetry, 31P NMR, x-ray diffraction, and optical spectroscopy revealed that this toxicity attenuation is related to the macromolecular structure of the complexes in a definable fashion. It is likely that amphotericin in this specific form will have a much improved therapeutic utility.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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