Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1988 Aug;85(16):6202–6206. doi: 10.1073/pnas.85.16.6202

Reexpression of a developmentally regulated antigen in Down syndrome and Alzheimer disease.

B Wolozin 1, A Scicutella 1, P Davies 1
PMCID: PMC281933  PMID: 2970636

Abstract

ALZ-50 is a monoclonal antibody that recognizes a protein of apparent molecular mass 68 kilodaltons (A68). The protein is present in the brains of patients with Alzheimer disease but is not detectable in normal adult brain tissue. We now report that ALZ-50-reactive neurons are found in normal fetal and neonatal human brain and in brain tissue from neonatal individuals with Down syndrome. Reactive neurons decrease sharply in number after age 2 and reappear in older individuals with Down syndrome and in patients with Alzheimer disease.

Full text

PDF
6202

Images in this article

6203Image
on p.6203
6205Image
on p.6205
6206Image
on p.6206

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Binder L. I., Frankfurter A., Rebhun L. I. Differential localization of MAP-2 and tau in mammalian neurons in situ. Ann N Y Acad Sci. 1986;466:145–166. doi: 10.1111/j.1749-6632.1986.tb38392.x. [DOI] [PubMed] [Google Scholar]
  2. Burger P. C., Vogel F. S. The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome. Am J Pathol. 1973 Nov;73(2):457–476. [PMC free article] [PubMed] [Google Scholar]
  3. Chun J. J., Nakamura M. J., Shatz C. J. Transient cells of the developing mammalian telencephalon are peptide-immunoreactive neurons. Nature. 1987 Feb 12;325(6105):617–620. doi: 10.1038/325617a0. [DOI] [PubMed] [Google Scholar]
  4. Goldgaber D., Lerman M. I., McBride O. W., Saffiotti U., Gajdusek D. C. Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science. 1987 Feb 20;235(4791):877–880. doi: 10.1126/science.3810169. [DOI] [PubMed] [Google Scholar]
  5. Heston L. L. Down's syndrome and Alzheimer's dementia: defining an association. Psychiatr Dev. 1984 Winter;2(4):287–294. [PubMed] [Google Scholar]
  6. Hyman B. T., Van Hoesen G. W., Wolozin B. L., Davies P., Kromer L. J., Damasio A. R. Alz-50 antibody recognizes Alzheimer-related neuronal changes. Ann Neurol. 1988 Apr;23(4):371–379. doi: 10.1002/ana.410230410. [DOI] [PubMed] [Google Scholar]
  7. Kang J., Lemaire H. G., Unterbeck A., Salbaum J. M., Masters C. L., Grzeschik K. H., Multhaup G., Beyreuther K., Müller-Hill B. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature. 1987 Feb 19;325(6106):733–736. doi: 10.1038/325733a0. [DOI] [PubMed] [Google Scholar]
  8. Kostovic I., Rakic P. Cytology and time of origin of interstitial neurons in the white matter in infant and adult human and monkey telencephalon. J Neurocytol. 1980 Apr;9(2):219–242. doi: 10.1007/BF01205159. [DOI] [PubMed] [Google Scholar]
  9. Luskin M. B., Shatz C. J. Studies of the earliest generated cells of the cat's visual cortex: cogeneration of subplate and marginal zones. J Neurosci. 1985 Apr;5(4):1062–1075. doi: 10.1523/JNEUROSCI.05-04-01062.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Matus A., Riederer B. Microtubule-associated proteins in the developing brain. Ann N Y Acad Sci. 1986;466:167–179. doi: 10.1111/j.1749-6632.1986.tb38393.x. [DOI] [PubMed] [Google Scholar]
  11. Pachter J. S., Liem R. K. The differential appearance of neurofilament triplet polypeptides in the developing rat optic nerve. Dev Biol. 1984 May;103(1):200–210. doi: 10.1016/0012-1606(84)90021-6. [DOI] [PubMed] [Google Scholar]
  12. Sidman R. L., Rakic P. Neuronal migration, with special reference to developing human brain: a review. Brain Res. 1973 Nov 9;62(1):1–35. doi: 10.1016/0006-8993(73)90617-3. [DOI] [PubMed] [Google Scholar]
  13. Tanzi R. E., Gusella J. F., Watkins P. C., Bruns G. A., St George-Hyslop P., Van Keuren M. L., Patterson D., Pagan S., Kurnit D. M., Neve R. L. Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science. 1987 Feb 20;235(4791):880–884. doi: 10.1126/science.2949367. [DOI] [PubMed] [Google Scholar]
  14. Wolozin B. L., Pruchnicki A., Dickson D. W., Davies P. A neuronal antigen in the brains of Alzheimer patients. Science. 1986 May 2;232(4750):648–650. doi: 10.1126/science.3083509. [DOI] [PubMed] [Google Scholar]
  15. Wolozin B., Davies P. Alzheimer-related neuronal protein A68: specificity and distribution. Ann Neurol. 1987 Oct;22(4):521–526. doi: 10.1002/ana.410220412. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES