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. 1988 Oct;85(19):7069–7073. doi: 10.1073/pnas.85.19.7069

The B- to Z-DNA equilibrium in vivo is perturbed by biological processes.

W Zacharias 1, A Jaworski 1, J E Larson 1, R D Wells 1
PMCID: PMC282125  PMID: 3050986

Abstract

Right-handed B and left-handed Z conformations coexist in equilibrium in portions of plasmids in Escherichia coli. The equilibria are influenced by the length of the sequences that undergo the structural transitions and are perturbed by biological processes. The composite results of three types of determinations indicate a supercoil density of -0.025 in vivo. The coexistence of alternative DNA conformations in living cells implies the potential of these structures or their transitions for important functions in genetic regulatory processes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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