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. 1988 Oct;85(19):7079–7083. doi: 10.1073/pnas.85.19.7079

Oligodeoxynucleoside phosphoramidates and phosphorothioates as inhibitors of human immunodeficiency virus.

S Agrawal 1, J Goodchild 1, M P Civeira 1, A H Thornton 1, P S Sarin 1, P C Zamecnik 1
PMCID: PMC282127  PMID: 3174622

Abstract

Modified oligodeoxynucleotides complementary to RNA of human immunodeficiency virus 1 (HIV-1) were tested for their ability to inhibit virally induced syncytium formation and expression of viral p24 protein. The modifications of oligomers include replacement of backbone phosphodiester groups with phosphorothioates and various phosphoramidates. All oligomers were found to be active. Oligomers with complete replacement of phosphodiesters with phosphoramidate or phosphorothioate groups were more active at the micromolar range than were unmodified oligomers of the same sequence. In addition, modified and unmodified homooligonucleotides also showed inhibition of HIV-1 replication. It is suggested that different classes of oligonucleotides may inhibit HIV replication by different mechanisms.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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