Table 3.
Associations Between Absolute Values of Year-5 FVC, FEV1, and FEV1/FVC Ratio and Year-15 Levels of Circulating Adhesion Molecules*
| Variables | Year-15 ICAM-1, ng/mL | Year-15 P-Selectin, ng/mL |
|---|---|---|
| Year 5 FVC | ||
| Q1 (≤ 3,609 mL) | 160.73 | 36.88 |
| Q2 (3,610–4,249 mL) | 152.62 | 37.18 |
| Q3 (4,250–5,089 mL) | 149.84 | 36.46 |
| Q4 (≥ 5,090 mL) | 148.09 | 36.26 |
| Q1–Q4,† ng/mL | 12.63 (3.92 to 21.35) | 0.63 (− 1.72 to 2.97) |
| p Value for trend | 0.01 | 0.76 |
| Year-5 FEV1 | ||
| Q1 (≤ 2,979 mL) | 159.98 | 37.69 |
| Q2 (2,980–3,499 mL) | 152.39 | 36.57 |
| Q3 (3,500–4,109 mL) | 152.67 | 36.71 |
| Q4 (≥ 4,110 mL) | 146.26 | 35.81 |
| Q1–Q4† | 13.72 (5.67 to 21.78) | 1.88 (− 0.29 to 4.05) |
| p Value for trend | 0.005 | 0.32 |
| Year-5 FEV1/FVC ratio | ||
| Q1 (≤ 77.9%) | 150.61 | 36.76 |
| Q2 (78.0–81.9%) | 151.58 | 36.52 |
| Q3 (82.0–85.9%) | 154.03 | 36.49 |
| Q4 (≥ 86.0%) | 155 | 37 |
| Q1–Q4,† ng/mL | − 4.39 (− 9.74 to 0.96) | − 0.24 (− 1.68 to 1.20) |
| p Value for trend | 0.33 | 0.88 |
*Tabulated values are estimates from models adjusting for race, gender, age, amount of physical activity, asthma status, smoking status, alcohol intake, and BMI, all at year 15, and height, height2 measured at year-0 and 5-year change (year 10 − year 5) in lung function (FVC, FEV1, and FEV1/FVC ratio). See Table 1 for abbreviation not used in the text.
†Values in parentheses are 95% confidence intervals.