Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1988 Oct;85(19):7298–7301. doi: 10.1073/pnas.85.19.7298

Algorithms for the restriction-site mapping of DNA molecules.

M Krawczak 1
PMCID: PMC282173  PMID: 2845405

Abstract

Two algorithms are described that rapidly construct restriction maps of DNA molecules from single- and double-digest data. The implementation of these algorithms into the Pascal programs AMAPK and AMARD allows such mapping to be done on microcomputers.

Full text

PDF
7298

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bellon B. Construction of restriction maps. Comput Appl Biosci. 1988 Mar;4(1):111–115. doi: 10.1093/bioinformatics/4.1.111. [DOI] [PubMed] [Google Scholar]
  2. Durand R., Bregegere F. An efficient program to construct restriction maps from experimental data with realistic error levels. Nucleic Acids Res. 1984 Jan 11;12(1 Pt 2):703–716. doi: 10.1093/nar/12.1part2.703. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Elder J. K., Amos A., Southern E. M., Shippey G. A. Measurement of DNA length by gel electrophoresis. I. Improved accuracy of mobility measurements using a digital microdensitometer and computer processing. Anal Biochem. 1983 Jan;128(1):223–226. doi: 10.1016/0003-2697(83)90368-8. [DOI] [PubMed] [Google Scholar]
  4. Elder J. K., Southern E. M. Measurement of DNA length by gel electrophoresis II: Comparison of methods for relating mobility to fragment length. Anal Biochem. 1983 Jan;128(1):227–231. doi: 10.1016/0003-2697(83)90369-x. [DOI] [PubMed] [Google Scholar]
  5. Nolan G. P., Maina C. V., Szalay A. A. Plasmid mapping computer program. Nucleic Acids Res. 1984 Jan 11;12(1 Pt 2):717–729. doi: 10.1093/nar/12.1part2.717. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Parker R. C., Watson R. M., Vinograd J. Mapping of closed circular DNAs by cleavage with restriction endonucleases and calibration by agarose gel electrophoresis. Proc Natl Acad Sci U S A. 1977 Mar;74(3):851–855. doi: 10.1073/pnas.74.3.851. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Pearson W. R. Automatic construction of restriction site maps. Nucleic Acids Res. 1982 Jan 11;10(1):217–227. doi: 10.1093/nar/10.1.217. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Polner G., Dorgai L., Orosz L. PMAP, PMAPS: DNA physical map constructing programs. Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):227–236. doi: 10.1093/nar/12.1part1.227. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Smith H. O., Birnstiel M. L. A simple method for DNA restriction site mapping. Nucleic Acids Res. 1976 Sep;3(9):2387–2398. doi: 10.1093/nar/3.9.2387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Southern E. M. Measurement of DNA length by gel electrophoresis. Anal Biochem. 1979 Dec;100(2):319–323. doi: 10.1016/0003-2697(79)90235-5. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES