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. 1988 Oct;85(19):7380–7383. doi: 10.1073/pnas.85.19.7380

Developmental changes in estrogen-sensitive neurons in the forebrain of the zebra finch.

M Gahr 1, M Konishi 1
PMCID: PMC282190  PMID: 3174641

Abstract

The brain areas for the control of song are sexually dimorphic in the zebra finch (Poephila guttata). Implantation of estrogen in young females within the first 40 days after hatching masculinizes their brain song areas. Monoclonal antibody (H222Sp gamma) against the estrogen receptor was used for the localization of estrogen-target cells in the brain. The nucleus hyperstriatum ventrale, pars caudale, was the only song control area that contained cells with estrogen-receptor sites. The number of these cells varied during ontogeny and declined sharply after day 40. No other song areas contained estrogen-target cells despite their ability to undergo masculine differentiation under the influence of estrogen. Therefore, the action of estrogen on these nuclei must be indirect.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bottjer S. W., Miesner E. A., Arnold A. P. Changes in neuronal number, density and size account for increases in volume of song-control nuclei during song development in zebra finches. Neurosci Lett. 1986 Jun 30;67(3):263–268. doi: 10.1016/0304-3940(86)90319-8. [DOI] [PubMed] [Google Scholar]
  2. Breedlove S. M. Cellular analyses of hormone influence on motoneuronal development and function. J Neurobiol. 1986 May;17(3):157–176. doi: 10.1002/neu.480170304. [DOI] [PubMed] [Google Scholar]
  3. Gahr M., Flügge G., Güttinger H. R. Immunocytochemical localization of estrogen-binding neurons in the songbird brain. Brain Res. 1987 Jan 27;402(1):173–177. doi: 10.1016/0006-8993(87)91063-8. [DOI] [PubMed] [Google Scholar]
  4. Greene G. L., Sobel N. B., King W. J., Jensen E. V. Immunochemical studies of estrogen receptors. J Steroid Biochem. 1984 Jan;20(1):51–56. doi: 10.1016/0022-4731(84)90188-2. [DOI] [PubMed] [Google Scholar]
  5. Gurney M. E. Hormonal control of cell form and number in the zebra finch song system. J Neurosci. 1981 Jun;1(6):658–673. doi: 10.1523/JNEUROSCI.01-06-00658.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gurney M. E., Konishi M. Hormone-induced sexual differentiation of brain and behavior in zebra finches. Science. 1980 Jun 20;208(4450):1380–1383. doi: 10.1126/science.208.4450.1380. [DOI] [PubMed] [Google Scholar]
  7. Konishi M., Akutagawa E. A critical period for estrogen action on neurons of the song control system in the zebra finch. Proc Natl Acad Sci U S A. 1988 Sep;85(18):7006–7007. doi: 10.1073/pnas.85.18.7006. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Konishi M., Akutagawa E. Hormonal control of cell death in a sexually dimorphic song nucleus in the zebra finch. Ciba Found Symp. 1987;126:173–185. doi: 10.1002/9780470513422.ch11. [DOI] [PubMed] [Google Scholar]
  9. Konishi M., Akutagawa E. Neuronal growth, atrophy and death in a sexually dimorphic song nucleus in the zebra finch brain. Nature. 1985 May 9;315(6015):145–147. doi: 10.1038/315145a0. [DOI] [PubMed] [Google Scholar]
  10. Krust A., Green S., Argos P., Kumar V., Walter P., Bornert J. M., Chambon P. The chicken oestrogen receptor sequence: homology with v-erbA and the human oestrogen and glucocorticoid receptors. EMBO J. 1986 May;5(5):891–897. doi: 10.1002/j.1460-2075.1986.tb04300.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Maxwell B. L., McDonnell D. P., Conneely O. M., Schulz T. Z., Greene G. L., O'Malley B. W. Structural organization and regulation of the chicken estrogen receptor. Mol Endocrinol. 1987 Jan;1(1):25–35. doi: 10.1210/mend-1-1-25. [DOI] [PubMed] [Google Scholar]
  12. Nordeen K. W., Nordeen E. J., Arnold A. P. Estrogen accumulation in zebra finch song control nuclei: implications for sexual differentiation and adult activation of song behavior. J Neurobiol. 1987 Nov;18(6):569–582. doi: 10.1002/neu.480180607. [DOI] [PubMed] [Google Scholar]
  13. Nottebohm F., Arnold A. P. Sexual dimorphism in vocal control areas of the songbird brain. Science. 1976 Oct 8;194(4261):211–213. doi: 10.1126/science.959852. [DOI] [PubMed] [Google Scholar]
  14. Nottebohm F., Stokes T. M., Leonard C. M. Central control of song in the canary, Serinus canarius. J Comp Neurol. 1976 Feb 15;165(4):457–486. doi: 10.1002/cne.901650405. [DOI] [PubMed] [Google Scholar]
  15. Siegel L. I., Akutagawa E., Fox T. O., Konishi M., Politch J. A. Androgen and estrogen receptors in adult zebra finch brain. J Neurosci Res. 1986;16(4):617–628. doi: 10.1002/jnr.490160404. [DOI] [PubMed] [Google Scholar]

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