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. Author manuscript; available in PMC: 2011 Feb 10.
Published in final edited form as: Vaccine. 2009 Dec 8;28(6):1454. doi: 10.1016/j.vaccine.2009.11.073

Figure 9. Molecular specificity of the MOMP antibody response after sequential infection with L2R and serovar Din L2R and sham-immunized mice.

Figure 9

The sera of five sham or L2R immunized and serovar D challenged mice analyzed in Figure 8 was tested by ELISA against synthetic peptide antigens corresponding to MOMP VDI and VDII of serovars D and L2. Previous studies have epitope mapped serovar D and L2 specific epitopes to VDII [18]. The VDs represent exposed loop structures on intact EBs and serovar-specific epitopes located in the loops are immunodominant and targets of neutralizing antibodies (Each bar represents the OD405nm mean ± SEM from each experimental group. Absorbance values for pre-immune sera were 0.1 or less.