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. 1988 Oct;85(20):7695–7698. doi: 10.1073/pnas.85.20.7695

Two monoclonal rat antibodies with specificity for the beta-chain variable region V beta 6 of the murine T-cell receptor.

J Payne 1, B T Huber 1, N A Cannon 1, R Schneider 1, M W Schilham 1, H Acha-Orbea 1, H R MacDonald 1, H Hengartner 1
PMCID: PMC282259  PMID: 2459713

Abstract

Two rat monoclonal antibodies (mAbs), 44-22-1 and 46-6B5, which recognize an alloreactive cytotoxic clone, 3F9, have been further tested on a panel of T hybridomas and cytotoxic T-cell clones for binding and functional activities. The mAbs recognized only those cells sharing the expression of the T-cell receptor beta-chain variable region gene V beta 6 with 3F9. All V beta 6+ cells were activated by these mAbs under cross-linking conditions and their antigen-specific activation was blocked by soluble mAb. Furthermore, depletion of 46-6B5+ normal lymph node T cells eliminated all cells expressing the epitope recognized by 44-22-1 and V beta 6 mRNA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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