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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1988 Nov;85(21):8008–8011. doi: 10.1073/pnas.85.21.8008

Maculosin, a host-specific phytotoxin for spotted knapweed from Alternaria alternata

Andrea C Stierle *, John H Cardellina II *,, Gary A Strobel
PMCID: PMC282343  PMID: 16593989

Abstract

Several diketopiperazines have been isolated from liquid cultures of Alternaria alternata, the causal agent of black leaf blight of spotted knapweed, Centaurea maculosa Lam. One of these compounds, maculosin [the diketopiperazine cyclo(-L-Pro-L-Tyr-)], was active in the nicked-leaf bioassay at 10-5 M; synthetic maculosin possessed chemical and biological activities identical to those of the natural product. Other diketopiperazines isolated from the fungus possessed either less activity or none at all. In tests against 19 plant species, maculosin was phytotoxic only to spotted knapweed. Thus maculosin is a host-specific phytotoxin from a weed pathogen.

Keywords: naturally occurring, herbicide, diketopiperazine, plant pathogen, leaf blight

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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