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. Author manuscript; available in PMC: 2010 Feb 17.
Published in final edited form as: Nature. 2008 May 28;454(7200):126–130. doi: 10.1038/nature06992

Figure 2. Consensus GGUG-containing RNA oligonucleotide promotes the inhibitory effect of TLS on CBP/p300 HAT activities.

Figure 2

a, Co-immunoprecipitation (IP) of p300 and TLS from RNase A-treated HeLa cells. b, P300 HAT activity was measured using micrococcal nuclease (MNase) or DNase I pre-treated GST and GST-TLS in the presence of GGUG- or CCUC-oligonucleotide. * p<0.02, compared with GST, n=3. c, d, The interaction of TLS N (1-211):C (373-526) termini (c) or GST-TLS:p300 (d) in the presence of GGUG- or CCUC-oligonucleotide. GST and GST-TLS were pre-treated with RNase A. Error bars indicate ± SEM.

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