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. 1988 Nov;85(21):8161–8165. doi: 10.1073/pnas.85.21.8161

Variable region (V delta) gene segment most frequently utilized in adult thymocytes is 3' of the constant (C delta) region.

M Iwashima 1, A Green 1, M M Davis 1, Y H Chien 1
PMCID: PMC282387  PMID: 3263646

Abstract

A variable region (V delta 5) of the T-cell receptor (TcR) delta chain that is preferentially expressed in adult murine thymocytes is located 2.5 kilobases 3' of the constant region (C delta) element. The V delta 5 coding sequence is in a transcriptional orientation opposite the J delta (joining region) and C delta coding elements and rearranges by inversion. The C delta is divided into four exons, three of which encode amino acids of TcR delta polypeptide, and the fourth comprises the entire 3' untranslated region. In this respect, C delta resembles C alpha rather than C beta or C gamma.

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