Table 1.
Model parameters.
| Parameter | Value | Description |
|---|---|---|
| vcluster | 5689.0 s−1 | Max. [Ca2+] channel flux |
| vleak | 0.020 35 s−1 | [Ca2+] leak flux constant |
| vpump | 45.5 μM s−1 | Max. [Ca2+] uptake |
| kpump | 0.1 μM | Activation constant for [Ca2+] pump |
| D | 25.0 μm2 s−1 | Effective diffusion coefficient of cytosolic [Ca2+] |
| Receptor binding constants | ||
| a1 | 167.6 (μM s)−1 | IP3 |
| a2 | 3.81 (μM s)−1 | Ca2+ inhibition |
| a3 | 413.4 (μM s)−1 | IP3 |
| a4 | 0.3101 (μM s)−1 | Ca2+ inhibition |
| a5 | 53.9 (μM s)−1 | Ca2+ activation |
| Receptor dissociation constants | ||
| b1 | 228.0 s−1 | IP3 |
| b2 | 0.409 s−1 | Ca2+ inhibition |
| b3 | 188.5 s−1 | IP3 |
| b4 | 0.096 s−1 | Ca2+ inhibition |
| b5 | 4.52 s−1 | Ca2+ activation |