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. 1988 Dec;85(23):9346–9350. doi: 10.1073/pnas.85.23.9346

Long-term potentiation differentially affects two components of synaptic responses in hippocampus.

D Muller 1, G Lynch 1
PMCID: PMC282736  PMID: 2904150

Abstract

We have used low magnesium concentrations and the specific antagonist D-2-amino-5-phosphonopentanoate (D-AP5) to estimate the effects of long-term potentiation (LTP) on the N-methyl-D-aspartate (NMDA) and non-NMDA receptor-mediated components of postsynaptic responses. LTP induction resulted in a considerably larger potentiation of non-NMDA as opposed to NMDA receptor-related currents. Increasing the size of postsynaptic potentials with greater stimulation currents or with paired-pulse facilitation produced opposite effects; i.e., those aspects of the response dependent on NMDA receptors increased to a greater degree than did those components mediated by non-NMDA receptors. These results pose new constraints on hypotheses about the locus and nature of LTP and strongly suggest that postsynaptic modifications are part of the effect.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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