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. 1988 Dec;85(24):9738–9742. doi: 10.1073/pnas.85.24.9738

Cytotoxic activity of an interleukin 6-Pseudomonas exotoxin fusion protein on human myeloma cells.

C B Siegall 1, V K Chaudhary 1, D J FitzGerald 1, I Pastan 1
PMCID: PMC282855  PMID: 3264406

Abstract

A chimeric toxin composed of human interleukin 6 (IL-6) attached to a portion of Pseudomonas exotoxin (PE) devoid of its own cell recognition domain has been produced in Escherichia coli. The fusion protein (IL-6-PE40) is cytotoxic to a human myeloma cell line expressing IL-6 receptors but has no effect on IL-6 receptor-negative cells. The specificity of IL-6-PE40 cytotoxicity was demonstrated through competition with excess IL-6 and neutralization with an antibody to IL-6. IL-6-PE40 may be useful in the selective elimination of myeloma cells and other cells with high numbers of IL-6 receptors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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